Guidelines for measuring cardiac physiology in mice

Merry L. Lindsey, Zamaneh Kassiri, Jitka A.I. Virag, Lisandra E. De Castro Brás, Marielle Scherrer-Crosbie

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Cardiovascular disease is a leading cause of death, and translational research is needed to understand better mechanisms whereby the left ventricle responds to injury. Mouse models of heart disease have provided valuable insights into mechanisms that occur during cardiac aging and in response to a variety of pathologies. The assessment of cardiovascular physiological responses to injury or insult is an important and necessary component of this research. With increasing consideration for rigor and reproducibility, the goal of this guidelines review is to provide best-practice information regarding how to measure accurately cardiac physiology in animal models. In this article, we define guidelines for the measurement of cardiac physiology in mice, as the most commonly used animal model in cardiovascular research.

Original languageEnglish (US)
Pages (from-to)H733-H752
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume314
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Cardiac physiology
  • Echocardiography
  • Hemodynamics
  • Magnetic resonance imaging
  • Rigor and reproducibility

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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