Gut microbiota: a non-target victim of pesticide-induced toxicity

Tusha Sharma, Nagabhishek Sirpu Natesh, Ramesh Pothuraju, Surinder K. Batra, Satyanarayana Rachagani

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The human gut microbiota can be potentially disrupted due to exposure of various environmental contaminants, including pesticides. These contaminants enter into non-target species in multiple ways and cause potential health risks. The gut microbiota-derived metabolites have a significant role in maintaining the host’s health by regulating metabolic homeostasis. An imbalance in this homeostasis can result in the development of various diseases and their pathogenesis. Pesticides have hazardous effects on the host’s gut microbiota, which is evident in a few recent studies. Therefore, there is an urgent need to explore the effect of pesticide on gut microbiota-mediated metabolic changes in the host, which may provide a better understanding of pesticide-induced toxicity. The present review summarizes the pesticide-induced effects on gut microbiota, which in turn, induces changes in the release of their secondary metabolites that could lead to various host health effects.

Original languageEnglish (US)
Article number2187578
JournalGut Microbes
Issue number1
StatePublished - 2023


  • Gut microbiota
  • heavy metals
  • organochlorine pesticides
  • organophosphate pesticides
  • persistent organic pollutants
  • pesticides

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Gastroenterology
  • Infectious Diseases


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