TY - JOUR
T1 - Hand Motor Actions of Children With Cerebral Palsy Are Associated With Abnormal Sensorimotor Cortical Oscillations
AU - Hoffman, Rashelle M.
AU - Wilson, Tony W.
AU - Kurz, Max J.
N1 - Funding Information:
Hoffman Rashelle M. DPT 1 https://orcid.org/0000-0002-5053-8306 Wilson Tony W. PhD 1 https://orcid.org/0000-0001-7040-5474 Kurz Max J. PhD 1 1 University of Nebraska Medical Center, Omaha, NE, USA Max J. Kurz, Department of Physical Therapy, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, 985450 Nebraska Medical Center, Omaha, NE 68198-5450, USA. Email: [email protected] 11 2019 1545968319883880 © The Author(s) 2019 2019 American Society of Neurorehabilitation Background. The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying the structural aberrations (eg, fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of hand movements. Objective. We aimed to start to fill this knowledge gap by using magnetoencephalographic brain imaging to quantify the temporal dynamics of the sensorimotor oscillations during a hand motor action. Methods : Children with CP (n = 12; MACS [Manual Abilities Classification System] levels I-III) and typically developing (TD) children (n = 26) performed an arrow-based version of the Eriksen flanker task where a button press was performed with either the second or third digit of the right hand depending on the arrow’s direction. Results : Overall, the children with CP were less accurate and had slower reaction times compared with the TD children. These behavioral differences were closely linked with aberrant sensorimotor cortical oscillations seen in the children with CP. Compared with the TD children, the children with CP had a weaker gamma (68-82 Hz) response during motor execution and a weaker post-movement beta rebound (PMBR; 14-26 Hz) response on movement termination. Moreover, we observed a significant correlation between the amplitude of the gamma and PMBR with reaction time, with weaker gamma and PMBR responses being linked with slower reaction times. Conclusions : Overall, these results suggest that aberrations in motor-related gamma and beta cortical oscillations are associated with the impaired hand motor actions seen in children with CP. magnetoencephalography MEG upper extremity finger motor control National Institute of Child Health and Human Development https://doi.org/10.13039/100000071 1R01-HD086245 NASA Nebraska Space Grant National Science Foundation https://doi.org/10.13039/100000001 NSF 1539067 edited-state corrected-proof Supplementary material for this article is available on the Neurorehabilitation & Neural Repair website at https://journals.sagepub.com/home/nnr . Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partially supported by grants from the National Institutes of Health (1R01-HD086245), the National Science Foundation (NSF 1539067), NASA Nebraska Space Grant, and the Promotion of Doctoral Studies I Scholarship from the Foundation for Physical Therapy Research. ORCID iDs Tony W. Wilson https://orcid.org/0000-0002-5053-8306 Max J. Kurz https://orcid.org/0000-0001-7040-5474
Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partially supported by grants from the National Institutes of Health (1R01-HD086245), the National Science Foundation (NSF 1539067), NASA Nebraska Space Grant, and the Promotion of Doctoral Studies I Scholarship from the Foundation for Physical Therapy Research.
Publisher Copyright:
© The Author(s) 2019.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Background. The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying the structural aberrations (eg, fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of hand movements. Objective. We aimed to start to fill this knowledge gap by using magnetoencephalographic brain imaging to quantify the temporal dynamics of the sensorimotor oscillations during a hand motor action. Methods: Children with CP (n = 12; MACS [Manual Abilities Classification System] levels I-III) and typically developing (TD) children (n = 26) performed an arrow-based version of the Eriksen flanker task where a button press was performed with either the second or third digit of the right hand depending on the arrow’s direction. Results: Overall, the children with CP were less accurate and had slower reaction times compared with the TD children. These behavioral differences were closely linked with aberrant sensorimotor cortical oscillations seen in the children with CP. Compared with the TD children, the children with CP had a weaker gamma (68-82 Hz) response during motor execution and a weaker post-movement beta rebound (PMBR; 14-26 Hz) response on movement termination. Moreover, we observed a significant correlation between the amplitude of the gamma and PMBR with reaction time, with weaker gamma and PMBR responses being linked with slower reaction times. Conclusions: Overall, these results suggest that aberrations in motor-related gamma and beta cortical oscillations are associated with the impaired hand motor actions seen in children with CP.
AB - Background. The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying the structural aberrations (eg, fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of hand movements. Objective. We aimed to start to fill this knowledge gap by using magnetoencephalographic brain imaging to quantify the temporal dynamics of the sensorimotor oscillations during a hand motor action. Methods: Children with CP (n = 12; MACS [Manual Abilities Classification System] levels I-III) and typically developing (TD) children (n = 26) performed an arrow-based version of the Eriksen flanker task where a button press was performed with either the second or third digit of the right hand depending on the arrow’s direction. Results: Overall, the children with CP were less accurate and had slower reaction times compared with the TD children. These behavioral differences were closely linked with aberrant sensorimotor cortical oscillations seen in the children with CP. Compared with the TD children, the children with CP had a weaker gamma (68-82 Hz) response during motor execution and a weaker post-movement beta rebound (PMBR; 14-26 Hz) response on movement termination. Moreover, we observed a significant correlation between the amplitude of the gamma and PMBR with reaction time, with weaker gamma and PMBR responses being linked with slower reaction times. Conclusions: Overall, these results suggest that aberrations in motor-related gamma and beta cortical oscillations are associated with the impaired hand motor actions seen in children with CP.
KW - MEG
KW - finger
KW - magnetoencephalography
KW - motor control
KW - upper extremity
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U2 - 10.1177/1545968319883880
DO - 10.1177/1545968319883880
M3 - Article
C2 - 31679451
AN - SCOPUS:85074728967
SN - 1545-9683
VL - 33
SP - 1018
EP - 1028
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
IS - 12
ER -