Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders

Jatin MacHhi, Bhavesh D. Kevadiya, Ijaz Khan Muhammad, Jonathan Herskovitz, Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalReview article

Abstract

Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage of the aggregated protein antigens into cervical lymph nodes serving to amplify effector immune responses. Both preclinical and clinical studies demonstrate transformation of this altered immunity for therapeutic gain. We posit that the signs and symptoms of common neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke can be attenuated by boosting Treg activities. Graphical Abstract: [Figure not available: See fulltext.].

Original languageEnglish (US)
Article number32
JournalMolecular neurodegeneration
Volume15
Issue number1
DOIs
StatePublished - Jun 5 2020

Keywords

  • Dendritic cells
  • Effector T cells (Teffs)
  • Immune transformation
  • Microglia
  • Neurodegenerative disorders
  • Regulatory T cells (Tregs)

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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