TY - JOUR
T1 - Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction
AU - Chalise, Upendra
AU - Becirovic-Agic, Mediha
AU - Rodriguez-Paar, Jocelyn R.
AU - Konfrst, Shelby R.
AU - de Morais, Sharon D.B.
AU - Johnson, Catherine S.
AU - Flynn, Elizabeth R.
AU - Hall, Michael E.
AU - Anderson, Daniel R.
AU - Cook, Leah M.
AU - DeLeon-Pennell, Kristine Y.
AU - Lindsey, Merry L.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2023/2
Y1 - 2023/2
N2 - To identify plasma proteins that mirror current and predict future remodeling after myocardial infarction (MI), we retrospectively interrogated plasma proteomes of day (D)0 control (n = 16) and D3 MI (n = 15) from C57BL/6 J mice (20 ± 1 months). A total of 165 unique proteins were correlated with cardiac physiology variables. We prospectively tested the hypothesis that candidates identified retrospectively would predict cardiac physiology at an extended timepoint (D7 MI) in a second cohort of mice (n = 4 ± 1 months). We also examined human plasma from healthy controls (n = 18) and patients 48 h after presentation for MI (n = 41). Retrospectively, we identified 5 strong reflectors of remodeling (all r ≥ 0.60 and p < 0.05). Prospectively, ApoA1, IgA, IL-17E, and TIMP-1 mirrored current and predicted future remodeling. In humans, cytokine-cytokine receptor signaling was the top enriched KEGG pathway for all candidates. In summary, we identified plasma proteins that serve as useful prognostic indicators of adverse remodeling and progression to heart failure. Graphical Abstract: [Figure not available: see fulltext.].
AB - To identify plasma proteins that mirror current and predict future remodeling after myocardial infarction (MI), we retrospectively interrogated plasma proteomes of day (D)0 control (n = 16) and D3 MI (n = 15) from C57BL/6 J mice (20 ± 1 months). A total of 165 unique proteins were correlated with cardiac physiology variables. We prospectively tested the hypothesis that candidates identified retrospectively would predict cardiac physiology at an extended timepoint (D7 MI) in a second cohort of mice (n = 4 ± 1 months). We also examined human plasma from healthy controls (n = 18) and patients 48 h after presentation for MI (n = 41). Retrospectively, we identified 5 strong reflectors of remodeling (all r ≥ 0.60 and p < 0.05). Prospectively, ApoA1, IgA, IL-17E, and TIMP-1 mirrored current and predicted future remodeling. In humans, cytokine-cytokine receptor signaling was the top enriched KEGG pathway for all candidates. In summary, we identified plasma proteins that serve as useful prognostic indicators of adverse remodeling and progression to heart failure. Graphical Abstract: [Figure not available: see fulltext.].
KW - ApoA1
KW - Echocardiography
KW - Infarct wall thinning
KW - Left ventricular dilation
KW - Outcomes
KW - Proteomics
KW - TIMP-1
KW - Wound healing
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U2 - 10.1007/s12265-022-10326-w
DO - 10.1007/s12265-022-10326-w
M3 - Article
C2 - 36197585
AN - SCOPUS:85139501680
SN - 1937-5387
VL - 16
SP - 3
EP - 16
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 1
ER -