TY - JOUR
T1 - Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C
AU - Maddux, Aline B.
AU - Berbert, Laura
AU - Young, Cameron C.
AU - Feldstein, Leora R.
AU - Zambrano, Laura D.
AU - Kucukak, Suden
AU - Newhams, Margaret M.
AU - Miller, Kristen
AU - FitzGerald, Madyson M.
AU - He, Jie
AU - Halasa, Natasha B.
AU - Cvijanovich, Natalie Z.
AU - Loftis, Laura L.
AU - Walker, Tracie C.
AU - Schwartz, Stephanie P.
AU - Gertz, Shira J.
AU - Tarquinio, Keiko M.
AU - Fitzgerald, Julie C.
AU - Kong, Michele
AU - Schuster, Jennifer E.
AU - Mack, Elizabeth H.
AU - Hobbs, Charlotte V.
AU - Rowan, Courtney M.
AU - Staat, Mary A.
AU - Zinter, Matt S.
AU - Irby, Katherine
AU - Crandall, Hillary
AU - Flori, Heidi
AU - Cullimore, Melissa L.
AU - Nofziger, Ryan A.
AU - Shein, Steven L.
AU - Gaspers, Mary Glas
AU - Hume, Janet R.
AU - Levy, Emily R.
AU - Chen, Sabrina R.
AU - Patel, Manish M.
AU - Tenforde, Mark W.
AU - Weller, Edie
AU - Campbell, Angela P.
AU - Randolph, Adrienne G.
N1 - Publisher Copyright:
© 2022 American Academy of Pediatrics. All rights reserved.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - OBJECTIVES: To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory abstract syndrome in children (MIS-C). METHODS: Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). RESULTS: Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04–1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06–1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55–6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35–4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C). CONCLUSIONS: Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.
AB - OBJECTIVES: To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory abstract syndrome in children (MIS-C). METHODS: Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). RESULTS: Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04–1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06–1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55–6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35–4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C). CONCLUSIONS: Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.
UR - http://www.scopus.com/inward/record.url?scp=85137138183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137138183&partnerID=8YFLogxK
U2 - 10.1542/peds.2022-057798
DO - 10.1542/peds.2022-057798
M3 - Article
C2 - 35765138
AN - SCOPUS:85137138183
SN - 0031-4005
VL - 150
JO - Pediatrics
JF - Pediatrics
IS - 3
M1 - e2022057798
ER -