Heart failure and protein quality control

Xuejun Wang, Jeffrey Robbins

Research output: Contribution to journalReview article

150 Scopus citations

Abstract

The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline physiological conditions, and cardiac stress may increase as a result of environmental or intrinsic pathological insults. Cardiomyocytes are continuously challenged to efficiently and properly fold nascent polypeptides, traffic them to their appropriate cellular locations, and keep them from denaturing in the face of normal and pathological stimuli. Because deployment of misfolded or unfolded proteins can be disastrous, cells, in general, and cardiomyocytes, in particular, have developed a multilayered protein quality control system for maintaining proper protein conformation and for reorganizing and removing misfolded or aggregated polypeptides. Here, we examine recent data pointing to the importance of protein quality control in cardiac homeostasis and disease.

Original languageEnglish (US)
Pages (from-to)1315-1328
Number of pages14
JournalCirculation Research
Volume99
Issue number12
DOIs
StatePublished - Dec 2006

Keywords

  • Cardiac disease
  • Cardiac failure
  • Cardiac muscle
  • Cardiomyocytes
  • Cardiovascular disease
  • Cardiovascular physiology

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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