Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model

S. J. Pirruccello, H. Nakamine, K. W. Beisel, K. L. Kleveland, M. Okano, Y. Taguchi, J. R. Davis, M. L. Mahloch, D. T. Purtilo

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23 Scopus citations

Abstract

In the course of evaluating the severe combined immunodeficiency mouse- human peripheral blood lymphocyte (SCID-PBL) model of lymphoproliferative disease, we noted hemagglutination occurring in peripheral blood smears of mice with serum human immunoglobulin levels greater than 1.0 mg/ml. The hemagglutinating process was mediated by human anti-mouse red cell antibodies of the IgM class, peaked at five to seven weeks post-transfer of 5 to 7 x 107 human PBL and was generally self limiting. However, death resulted in some mice when serum immunoglobulin levels were greater than 3.0 mg/ml. The most severely affected mice had hemagglutination induced congestion of liver, lungs and spleen. Several mice also had lesions consistent with graft-versus- host disease (GVHD) including focal hepatic necrosis and destruction of mouse splenic hematopoietic elements. The lesions associated with hemagglutination and GVHD in SCID-PBL mice are distinct from those associated with EBV-induced lymphoproliferation. Recognition of these pathologic processes are required for a thorough understanding of the SCID-PBL model.

Original languageEnglish (US)
Pages (from-to)1187-1194
Number of pages8
JournalAmerican Journal of Pathology
Volume140
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Pirruccello, S. J., Nakamine, H., Beisel, K. W., Kleveland, K. L., Okano, M., Taguchi, Y., Davis, J. R., Mahloch, M. L., & Purtilo, D. T. (1992). Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model. American Journal of Pathology, 140(5), 1187-1194.