Hemodynamic effects of centrally administered adrenomedullin (13–52) in anesthetized rats

Y. J. Wei, Q. Tian, Q. H. Li, Y. L. Li, J. K. Chang, J. Tang, S. Y. Ho

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This study was conducted to investigate the effect of intracerebroventricular administration of adrenomedullin (13–52) [ADM(13–52)], a novel hypotensive peptide, on the hemodynamic parameters of anesthetized rats. ADM(13–52) was administered centrally in a dose of 0.4–3.2 nmol/kg. It provoked marked, prolonged and dose-dependent increases in mean arterial blood pressure, heart rate, stroke volume, cardiac index, left ventricular pressure, left ventricular dp/dtmaxand dp/dtmin but reduction in total peripheral resistance index. In addition, intracerebroventricular administration of ADM(13–52; 1.6 nmol/kg) provoked a marked increase in renal sympathetic nerve activity. Intracerebroventricular administration of artificial cerebrospinal fluid had no effect on the hemodynamic parameters and renal sympathetic nerve activity. The results indicate that ADM(13–52) exerts a central action on the cardiovascular system. The mechanisms of hemodynamic changes induced by central ADM(13–52) were preliminarily analyzed in this study. ADM might play a role in the central control of the cardiovascular system, although the confirmed mechanisms and the physiological implications are undetermined.

Original languageEnglish (US)
Pages (from-to)338-344
Number of pages7
JournalNeuroSignals
Volume4
Issue number6
DOIs
StatePublished - 1995

Keywords

  • Adrenomedullin (13–52)
  • Blood pressure, mean arterial
  • Cardiac index
  • Heart rate
  • Left ventricular pressure
  • Peripheral resistance index, total
  • Stroke volume
  • Sympathetic nerve activity, renal

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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