Hemodynamically motivated choice of patch angioplasty for the performance of carotid endarterectomy

Alexey V. Kamenskiy, Jason N. MacTaggart, Iraklis I. Pipinos, Prateek K. Gupta, Yuris A. Dzenis

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Patch angioplasty is the most common technique used for the performance of carotid endarterectomy. A large number of materials are available, but little is known to aid the surgeon in choosing a patch while caring for a patient with carotid disease. The objective of this study was to investigate biomechanics of the carotid artery (CA) repaired with patch angioplasty, study the influence of patch width and location of closure on hemodynamics, and to select the optimal patch material from those commonly used. For this purpose, a mathematical model was built that accounts for fluid-structure interaction, three-dimensional arterial geometry, non-linear anisotropic mechanical properties, non-Newtonian flow and in vivo boundary conditions. This model was used to study disease-related mechanical factors in the arterial wall and blood flow for different types of patch angioplasty. Analysis indicated that patch closures performed with autologous vein and bovine pericardium were hemodynamically superior to carotid endarterectomy with synthetic patch angioplasty (polytetrafluoroethylene, Dacron) in terms of restenosis potential. Width of the patch and location of arteriotomy were found to be of paramount importance, with narrow patches being superior to wide patches, and anterior arteriotomy being superior to the lateral arteriotomy. These data can aid vascular surgeons in their selection of patch angioplasty technique and material for the care of patients undergoing open CA repair.

Original languageEnglish (US)
Pages (from-to)263-278
Number of pages16
JournalAnnals of biomedical engineering
Issue number2
StatePublished - Feb 2013


  • Atherosclerosis
  • Carotid artery
  • Endarterectomy
  • Finite element analysis
  • Hemodynamics
  • Patch angioplasty
  • Restenosis

ASJC Scopus subject areas

  • Biomedical Engineering


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