TY - JOUR
T1 - Heparin-induced antiheparin-platelet antibody associated with retinal venous thrombosis
AU - Nguyen, Quan Dong
AU - Van Do, Diana
AU - Feke, Gilbert T.
AU - Nazareth Demirjian, Zareh
AU - Lashkari, Kameran
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Objective: To report a case of a 33-year-old white woman in whom retinal venous thromboses developed secondary to heparin-induced antiheparin-platelet antibodies. Design: Interventional case report. Methods: The patient underwent complete ophthalmic and medical examinations. Laser Doppler measurement of retinal blood circulation also was performed. Intervention: Prolonged anticoagulation with thrombin inhibitors and warfarin. Main Outcome Measures: Visual symptoms, retinal appearance on clinical examination, and measurement of retinal blood flow by laser Doppler technique. Results: The patient experienced a scotoma in the visual field of the left eye, left retinal venous thrombosis, decreased venous blood flow in the left eye, and heparin-induced antiheparin-platelet antibodies in serum. After intervention, the visual symptoms and retinal appearance improved, and retinal blood flow normalized. Conclusions: Heparin-induced antiheparin-platelet antibody can lead to thrombosis of the ocular circulation. This index case, which is the first one ever reported in association with antiheparin-platelet antibodies, further illustrates the potential side effects of heparin and widens the spectrum of complications of heparin-induced thrombocytopenia (HIT) and HIT thrombosis syndrome (HITTS).
AB - Objective: To report a case of a 33-year-old white woman in whom retinal venous thromboses developed secondary to heparin-induced antiheparin-platelet antibodies. Design: Interventional case report. Methods: The patient underwent complete ophthalmic and medical examinations. Laser Doppler measurement of retinal blood circulation also was performed. Intervention: Prolonged anticoagulation with thrombin inhibitors and warfarin. Main Outcome Measures: Visual symptoms, retinal appearance on clinical examination, and measurement of retinal blood flow by laser Doppler technique. Results: The patient experienced a scotoma in the visual field of the left eye, left retinal venous thrombosis, decreased venous blood flow in the left eye, and heparin-induced antiheparin-platelet antibodies in serum. After intervention, the visual symptoms and retinal appearance improved, and retinal blood flow normalized. Conclusions: Heparin-induced antiheparin-platelet antibody can lead to thrombosis of the ocular circulation. This index case, which is the first one ever reported in association with antiheparin-platelet antibodies, further illustrates the potential side effects of heparin and widens the spectrum of complications of heparin-induced thrombocytopenia (HIT) and HIT thrombosis syndrome (HITTS).
UR - http://www.scopus.com/inward/record.url?scp=0037372187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037372187&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(02)01766-9
DO - 10.1016/S0161-6420(02)01766-9
M3 - Article
C2 - 12623829
AN - SCOPUS:0037372187
SN - 0161-6420
VL - 110
SP - 600
EP - 603
JO - Ophthalmology
JF - Ophthalmology
IS - 3
ER -