Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)

D. J. Tuma; M. F. Sorrell; A. J. Barak

doi:10.3181/00379727-146-38226

Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)

D. J. Tuma, M. F. Sorrell, A. J. Barak

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.

Original language	English (US)
Pages (from-to)	953-956
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	146
Issue number	4
DOIs	https://doi.org/10.3181/00379727-146-38226
State	Published - Sep 1974

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)",

abstract = "Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.",

author = "Tuma, {D. J.} and Sorrell, {M. F.} and Barak, {A. J.}",

note = "Funding Information: This investigator was supported in part by an Academic Career Development Award #AM 70316 from the National Institutes of Arthritis and Digestive Diseases.",

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T1 - Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)

AU - Tuma, D. J.

AU - Sorrell, M. F.

AU - Barak, A. J.

N1 - Funding Information: This investigator was supported in part by an Academic Career Development Award #AM 70316 from the National Institutes of Arthritis and Digestive Diseases.

PY - 1974/9

Y1 - 1974/9

N2 - Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.

AB - Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.

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Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)

Abstract

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