Hepatic complications of hematopioetic cell transplantation

Josh Levitsky, Michael F. Sorrell

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Acute and chronic liver disease contributes significantly to morbidity and mortality following hematopoietic cell transplantation (HCT). The best prognostic indicator for the development of severe liver dysfunction is an early rise in liver function test results after HCT. The leading causes soon after HCT are acute graft-versu s- host disease (GVHD), sinusoidal obstruction syndrome, drug and total parenteral nutrition hepatotoxicity, sepsis, and viral infection. Hepatic herpesvirus and fungal infections after HCT, though uncommon, can be life-threatening and warrant immediate diagnosis and treatment. Hepatitis B, hepatitis C virus, iron overload, and chronic GVHD are among the most common causes for chronic liver disease after HCT. Because treatments are directed at the underlying etiology of liver disease, prompt diagnosis by means of laboratory tests, hepatic imaging, and often liver biopsy is required after HCT.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalCurrent gastroenterology reports
Volume9
Issue number1
DOIs
StatePublished - Mar 2007
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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