Hepatic Failure Associated with Imipramine Therapy

Mark S. Shaefer; Ann L. Edmunds; Rodney S. Markin; R. Patrick Wood; Todd J. Pillen; B. W. Shaw

doi:10.1002/j.1875-9114.1990.tb02551.x

Hepatic Failure Associated with Imipramine Therapy

Mark S. Shaefer, Ann L. Edmunds, Rodney S. Markin, R. Patrick Wood, Todd J. Pillen, B. W. Shaw

Research output: Contribution to journal › Article › peer-review

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Abstract

Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11‐year‐old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation. 1990 Pharmacotherapy Publications Inc.

Original language	English (US)
Pages (from-to)	66-69
Number of pages	4
Journal	Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume	10
Issue number	1
DOIs	https://doi.org/10.1002/j.1875-9114.1990.tb02551.x
State	Published - 1990

ASJC Scopus subject areas

Pharmacology (medical)

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10.1002/j.1875-9114.1990.tb02551.x

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AU - Edmunds, Ann L.

AU - Markin, Rodney S.

AU - Wood, R. Patrick

AU - Pillen, Todd J.

AU - Shaw, B. W.

PY - 1990

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AB - Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11‐year‐old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation. 1990 Pharmacotherapy Publications Inc.

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Hepatic Failure Associated with Imipramine Therapy

Abstract

ASJC Scopus subject areas

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