TY - JOUR
T1 - Hepatitis B Virus X Protein-Induced ROR γ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma
AU - Huang, Yu
AU - Liang, Huasheng
AU - He, Chuanxiong
AU - Peng, Fang
AU - Hu, Guoku
N1 - Funding Information:
γ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma Huang Yu [email protected] 1 https://orcid.org/0000-0002-2563-4363 Liang Huasheng [email protected] 2 He Chuanxiong [email protected] 3 Peng Fang [email protected] 2 Hu Guoku 1 Department of Hepatobiliary Surgery The Guangxi Zhuang Autonomous Region People’s Hospital Nanning 530021 China gxhospital.com 2 Beihai Institute of Endocrine and Metabolic Diseases Ninth Affiliated Hospital of Guangxi Medical University Beihai 536000 China 3 Guangxi Beihai Second People’s Hospital Beihai 536000 China 2019 3 11 2019 2019 08 07 2019 04 09 2019 13 09 2019 3 11 2019 2019 Copyright © 2019 Yu Huang et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aberrant expression of ROR γ is implicated in cancer development. A previous study identified that ROR γ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its expression and significance in HCC remain unclear. The central finding of this work is that ROR γ was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of ROR γ in hepatocellular carcinoma through enhancing the transcriptional function. Also, the HBx-induced ROR γ could promote the migration and proliferation of hepatoma cells. Hence, these results suggest that ROR γ was an important regulator in HCC, and our finding provides new insights into the significance of ROR γ in HCC. Natural Science Foundation of Guangxi Province 2013GXNSFDA019019 Project of “139” Plan for Training High Level Cadre Talents in Guangxi Medicine Cultivating Academic and Technical Leaders Guangxi New Century Ten Hundred and Thousand Talents Project
Publisher Copyright:
© 2019 Yu Huang et al.
PY - 2019
Y1 - 2019
N2 - Aberrant expression of RORγ is implicated in cancer development. A previous study identified that RORγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its expression and significance in HCC remain unclear. The central finding of this work is that RORγ was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of RORγ in hepatocellular carcinoma through enhancing the transcriptional function. Also, the HBx-induced RORγ could promote the migration and proliferation of hepatoma cells. Hence, these results suggest that RORγ was an important regulator in HCC, and our finding provides new insights into the significance of RORγ in HCC.
AB - Aberrant expression of RORγ is implicated in cancer development. A previous study identified that RORγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its expression and significance in HCC remain unclear. The central finding of this work is that RORγ was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of RORγ in hepatocellular carcinoma through enhancing the transcriptional function. Also, the HBx-induced RORγ could promote the migration and proliferation of hepatoma cells. Hence, these results suggest that RORγ was an important regulator in HCC, and our finding provides new insights into the significance of RORγ in HCC.
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U2 - 10.1155/2019/5407126
DO - 10.1155/2019/5407126
M3 - Article
C2 - 31781621
AN - SCOPUS:85075304869
SN - 2314-6133
VL - 2019
JO - BioMed research international
JF - BioMed research international
M1 - 5407126
ER -