Hepatocellular calcification in severe ischemia-Reperfusion injury in a liver allograft

Geoffrey A. Talmon, James L. Wisecarver

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Ischemiareperfusion injury (IR) of solid organ allografts is a consequence of ischemia resulting from disruption of blood flow during organ harvest and transportation. Histologically, this manifests as variable necrosis in a pattern similar to that seen in systemic hypoperfusion. Calcification of hepatocytes has been rarely observed in ischemic injury due to systemic shock and in two cases of severe IR, both of which were associated with graft loss and death. The authors present another case of dystrophic calcification within hepatocytes occurring in a liver allograft affected by severe IR. Biochemical stains revealed that the mineralized material was calcium phosphate (likely hydroxyapatite). By electron microscopy, the hepatocyte cytoplasm was filled with variably calcified vacuoles, a subset of which likely represented swollen mitochondria. When encountered in hepatic allograft biopsies, hepatocellular calcification is associated with ischemic injury and a poor prognosis.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalUltrastructural Pathology
Issue number6
StatePublished - Dec 2010


  • Calcification
  • Calcium phosphate
  • Ischemia
  • Liver
  • Mitochondria
  • Transplantation

ASJC Scopus subject areas

  • Structural Biology
  • Pathology and Forensic Medicine


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