Hepatocellular carcinoma pathogenesis: From genes to environment

Paraskevi A. Farazi, Ronald A. DePinho

Research output: Contribution to journalReview articlepeer-review

1603 Scopus citations


Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population. Despite its significance, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive disease pathogenesis, and there are only limited therapeutic options, many with negligible clinical benefit. This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis.

Original languageEnglish (US)
Pages (from-to)674-687
Number of pages14
JournalNature Reviews Cancer
Issue number9
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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