TY - JOUR
T1 - Hepatosplenic γ-δ T-Cell Lymphoma
T2 - Who Is on Your Speed Dial?
AU - Krishnan, Mridula
AU - Lunning, Matthew
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Hepatosplenic γ-δ T-cell lymphoma, an exceptionally uncommon subtype of peripheral T-cell lymphomas, commonly presents with advanced-stage disease manifesting with hepatosplenomegaly, cytopenias, and constitutional symptoms. Management of this subset is challenging as a result of the unique presentation and refractory nature to conventional treatment approaches. There is a lack of consensus guidelines for up-front induction strategies, and the role of consolidative autologous or allogeneic stem-cell transplantation is controversial. Prospective studies are lacking, and treatment is often guided by literature on the basis of case series or single-institution studies, lending to expert opinions influencing treatment paradigms.
AB - Hepatosplenic γ-δ T-cell lymphoma, an exceptionally uncommon subtype of peripheral T-cell lymphomas, commonly presents with advanced-stage disease manifesting with hepatosplenomegaly, cytopenias, and constitutional symptoms. Management of this subset is challenging as a result of the unique presentation and refractory nature to conventional treatment approaches. There is a lack of consensus guidelines for up-front induction strategies, and the role of consolidative autologous or allogeneic stem-cell transplantation is controversial. Prospective studies are lacking, and treatment is often guided by literature on the basis of case series or single-institution studies, lending to expert opinions influencing treatment paradigms.
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U2 - 10.1200/JOP.18.00594
DO - 10.1200/JOP.18.00594
M3 - Article
C2 - 31185190
AN - SCOPUS:85067813029
SN - 1554-7477
VL - 15
SP - 307
EP - 312
JO - Journal of oncology practice
JF - Journal of oncology practice
IS - 6
ER -