Hereditary Diffuse Gastric Cancer: Prophylactic Surgical Oncology Implications

Henry T. Lynch, Edibaldo Silva, Debrah Wirtzfeld, Pamela Hebbard, Jane Lynch, David G. Huntsman

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option for CDH1 carriers is prophylactic total gastrectomy, but the variable age of onset of HDGC and the reduced penetrance (about 70%) of the CDHI gene further complicate patients' decision making.

Original languageEnglish (US)
Pages (from-to)759-778
Number of pages20
JournalSurgical Clinics of North America
Issue number4
StatePublished - Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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