Herpesvirus-transformed cytotoxic T-cell lines

Donald R. Johnson, Mikael Jondal

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Investigations of cellular cytotoxicity of the immune system are hampered by the lack of continuously growing, transformed cell lines which express a cytotoxic potential. Here we describe cytotoxic cell lines from the cotton-topped marmoset monkey, transformed by Herpesvirus Ateles (HVA) or Herpesvirus Saimiri (HVS), which can kill certain target cells in a short-term in vitro test. HVA/HVS-transformed cells have earlier been classified as belonging to the T-cell lineage1-3 in contrast to Epstein-Barr virus (EBV)-transformed cells derived from B lymphocytes4. We suggest that the HVA/HVS-transformed killer cell lines described here represent an effector population resembling, or corresponding to, marmoset natural killer (NK) cells and that they may be used to define the cytolytic mechanism involved in cellular cytotoxicity and possibly also effector cell receptors and target cell antigens, as well as regulatory mechanisms of general biological interest.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalNature
Volume291
Issue number5810
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • General

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