Heteromorphism of C-band positive chromosomal regions in CML patients

Siddharth G. Adhvaryu, Bhavana J. Dave, Amit H. Trivedi, Kalyani H. Jani, Rohini C. Vyas

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalCancer genetics and cytogenetics
Volume27
Issue number1
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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