Heteromorphism of C-band positive chromosomal regions in CML patients

Siddharth G. Adhvaryu; Bhavana J. Dave; Amit H. Trivedi; Kalyani H. Jani; Rohini C. Vyas

doi:10.1016/0165-4608(87)90257-3

Heteromorphism of C-band positive chromosomal regions in CML patients

Siddharth G. Adhvaryu, Bhavana J. Dave, Amit H. Trivedi, Kalyani H. Jani, Rohini C. Vyas

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

Original language	English (US)
Pages (from-to)	33-38
Number of pages	6
Journal	Cancer genetics and cytogenetics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(87)90257-3
State	Published - Jul 1987
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Heteromorphism of C-band positive chromosomal regions in CML patients",

abstract = "The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.",

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AU - Trivedi, Amit H.

AU - Jani, Kalyani H.

AU - Vyas, Rohini C.

PY - 1987/7

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N2 - The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

AB - The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

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Heteromorphism of C-band positive chromosomal regions in CML patients

Abstract

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