High-dose chemotherapy and autologous hematopoietic stem-cell transplantation for aggressive non-Hodgkin's lymphoma

Julie Marie Vose, James R. Anderson, Anne Kessinger, Philip Jay Bierman, Peter Coccia, Elizabeth Cecile Reed, Bruce Geoffrey Gordon, James Olen Armitage

Research output: Contribution to journalArticlepeer-review

240 Scopus citations


Purpose: To evaluate clinical and tumor characteristics in patients receiving high-dose chemotherapy and autologous peripheral stem-cell transplantation (PSCT) or bone marrow transplantation (ABMT) for relapsed or primary refractory non-Hodgkin's lymphoma (NHL). Patients and Methods: One hundred fifty-eight patients with NHL received high-dose chemotherapy and ABMT or PSCT. A multivariate analysis of characteristics was performed for comparison of the long-term failure-free survival (FFS) rate. Results: Using a multivariate analysis, a prognostic model was constructed with patients in the good-prognosis group being those without a mass ≥ 10 cm at the time of transplant, and no more than one of the following characteristics: three or more prior chemotherapy regimens, lactate dehydrogenase (LDH) level above normal, and chemotherapy resistance. Patients in the poor-prognosis group had a mass ≥ 10 cm, or two of the other characteristics noted. The poor-prognosis group had a 3-year FFS rate of 10%, compared with a 45% 3-year FFS in the good-prognosis group (P < .001). Within the prognostic groups, there was no difference in the 3-year FFS rate of the poor-prognosis patients who received ABMT versus PSCT (10% v 12%; not significant). However, in the good-prognosis group, patients who received ABMT had a 3-year FFS rate of 32%, compared with 70% for those who received PSCT (P < .008). Conclusion: This prognostic model can identify patients with good and poor prognoses following high-dose chemotherapy and ABMT or PSCT for aggressive NHL. In good-prognosis patients, those who received PSCT had a superior FFS rate.

Original languageEnglish (US)
Pages (from-to)1846-1851
Number of pages6
JournalJournal of Clinical Oncology
Issue number10
StatePublished - 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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