TY - JOUR
T1 - High dose therapy and autologous marrow transplantation as salvage treatment for patients with diffuse large cell lymphoma
AU - Armitage, James O.
AU - Jagannath, Sundar
AU - Spitzer, Gary
AU - Bierman, Phil
AU - Kessinger, Anne
AU - Kumar, Pradeep
AU - Cabanillas, Fernando
AU - Zander, Axel
AU - Vellekoop, Lijda
AU - Dicke, Karel A.
PY - 1986/7
Y1 - 1986/7
N2 - Twenty-nine patients with diffuse large cell lymphoma who failed traditional chemotherapy were treated with high dose chemotherapy with or without total body irradiation followed by infusion of cryopreserved autologous marrow. Complete response was achieved in 11 29 patients (38%), partial response in 13 29 patients (45%) and 5 29 patients (17%) had no response. Six complete responders remain well and free of disease for 5+, 6+, 9+, 10+, 18+ and 25+ months, 3 relapsed at 2, 3 and 8 months after marrow infusion, and 2 died from infectious complications. Complete response was seen more frequently with the absence of bulky tumor (70 vs 21%, P = 0.03), a total body irradiation containing regimen (52 vs 0%, P = 0.03), a history of complete remission with initial chemotherapy (55% vs. 9%, P = 0.03), and a performance status ≥ 80 (56 vs 15%, P = 0.06). High dose therapy had a high response rate (83%) in resistant diffuse large cell lymphoma and yielded durable complete responses in a minority of these patients.
AB - Twenty-nine patients with diffuse large cell lymphoma who failed traditional chemotherapy were treated with high dose chemotherapy with or without total body irradiation followed by infusion of cryopreserved autologous marrow. Complete response was achieved in 11 29 patients (38%), partial response in 13 29 patients (45%) and 5 29 patients (17%) had no response. Six complete responders remain well and free of disease for 5+, 6+, 9+, 10+, 18+ and 25+ months, 3 relapsed at 2, 3 and 8 months after marrow infusion, and 2 died from infectious complications. Complete response was seen more frequently with the absence of bulky tumor (70 vs 21%, P = 0.03), a total body irradiation containing regimen (52 vs 0%, P = 0.03), a history of complete remission with initial chemotherapy (55% vs. 9%, P = 0.03), and a performance status ≥ 80 (56 vs 15%, P = 0.06). High dose therapy had a high response rate (83%) in resistant diffuse large cell lymphoma and yielded durable complete responses in a minority of these patients.
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U2 - 10.1016/0277-5379(86)90376-7
DO - 10.1016/0277-5379(86)90376-7
M3 - Article
C2 - 3533557
AN - SCOPUS:0022506937
SN - 0277-5379
VL - 22
SP - 871
EP - 877
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
IS - 7
ER -