High-dose therapy and autologous peripheral blood stem cell transplantation for patients with lymphoma

A. Kessinger, J. O. Armitage, D. M. Smith, J. D. Landmark, P. J. Bierman, D. D. Weisenburger

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

Forty patients with refractory Hodgkin's disease (24 patients) or non-Hodgkin's lymphoma (16 patients) who were considered for high-dose therapy but not for autologous bone marrow transplantation (ABMT) due to BM metastases, previous pelvic irradiation, a history of marrow involvement by tumor or hypocellular marrow in conventional harvest sites received high-dose therapy and autologous peripheral blood (PB) hematopoietic stem cell transplantation. Disappearance of circulating neutrophils and development of RBC and platelet transfusion-dependence was followed, in the evaluable patients, by reappearance of 0.5 x 109/L circulating granulocytes and sufficient platelets to obviate the need for platelet transfusions at a median of 25 days after transplantation. Twenty-three patients experienced a clinical complete remission (CR). The projected 2-year event-free survival was 25% for all 40 patients and 49% for the non-Hodgkin's lymphoma patients. The projected 18-month event-free survival for the Hodgkin's disease patients was 15%. PB stem cell transplantation provided an opportunity to administer high-dose salvage therapy to patients with refractory lymphoma who otherwise were not candidates for such therapy. For some of those patients, the high-dose therapy produced prolonged survival, free of tumor progression.

Original languageEnglish (US)
Pages (from-to)1260-1265
Number of pages6
JournalBlood
Volume74
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Kessinger, A., Armitage, J. O., Smith, D. M., Landmark, J. D., Bierman, P. J., & Weisenburger, D. D. (1989). High-dose therapy and autologous peripheral blood stem cell transplantation for patients with lymphoma. Blood, 74(4), 1260-1265.