High-grade transformation of low-grade B-cell lymphoma

Rose Lou Marie C. Agbay, Sanam Loghavi, L. Jeffrey Medeiros, Joseph D. Khoury

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Patients with low-grade (clinically indolent) lymphomas are at risk to undergo transformation to high-grade (clinically aggressive) lymphoma, although transformation only occurs in a subset of patients. When transformation occurs it is a critical event that determines the course of disease and is associated with unfavorable patient outcomes. Accurate detection of transformation, predictive biomarkers, and identification of specific molecular pathways implicated in the pathobiology of transformation will facilitate personalized therapeutic approaches and underpin advances in clinical outcomes. In this article, we present an update of the clinical and pathologic diagnostic criteria for low-grade B-cell lymphoma transformation and discuss the molecular alterations involved in the pathogenesis of this biological phenomenon.

Original languageEnglish (US)
Pages (from-to)e1-e16
JournalAmerican Journal of Surgical Pathology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • B-cell lymphoma
  • DLBCL
  • Hodgkin
  • low-grade
  • molecular
  • transformation

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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