High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Michael Green; Maher K. Gandhi; Emily Camilleri; Paula Marlton; Rod Lea; Lyn Griffiths

doi:10.1016/j.leukres.2008.09.007

High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Michael Green, Maher K. Gandhi, Emily Camilleri, Paula Marlton, Rod Lea, Lyn Griffiths

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown

Original language	English (US)
Pages (from-to)	731-734
Number of pages	4
Journal	Leukemia Research
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2008.09.007
State	Published - May 2009
Externally published	Yes

Keywords

BACH2
BCL2
Diffuse large B-cell lymphoma
Follicular lymphoma
Non-Hodgkin's lymphoma
t(14 ;18)(q21 ;q34)

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2008.09.007

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@article{67e67887ff164a37b08bf786d06461fe,

title = "High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma",

abstract = "The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown",

keywords = "BACH2, BCL2, Diffuse large B-cell lymphoma, Follicular lymphoma, Non-Hodgkin's lymphoma, t(14 ;18)(q21 ;q34)",

author = "Michael Green and Gandhi, {Maher K.} and Emily Camilleri and Paula Marlton and Rod Lea and Lyn Griffiths",

note = "Funding Information: We would like to acknowledge the Australasian Leukaemia and Lymphoma Group Tissue Bank for the provision of haematologic malignancy samples for this project. The ALLG Tissue Bank is supported by PricewaterhouseCoopers, the Leukaemia Foundation of Australia and National Health and Medical Research funding. This work is supported by funding from the Griffith Medical Research College and the Herbert Family.",

year = "2009",

month = may,

doi = "10.1016/j.leukres.2008.09.007",

language = "English (US)",

volume = "33",

pages = "731--734",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

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T1 - High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

AU - Green, Michael

AU - Gandhi, Maher K.

AU - Camilleri, Emily

AU - Marlton, Paula

AU - Lea, Rod

AU - Griffiths, Lyn

N1 - Funding Information: We would like to acknowledge the Australasian Leukaemia and Lymphoma Group Tissue Bank for the provision of haematologic malignancy samples for this project. The ALLG Tissue Bank is supported by PricewaterhouseCoopers, the Leukaemia Foundation of Australia and National Health and Medical Research funding. This work is supported by funding from the Griffith Medical Research College and the Herbert Family.

PY - 2009/5

Y1 - 2009/5

N2 - The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown

AB - The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown

KW - BACH2

KW - BCL2

KW - Diffuse large B-cell lymphoma

KW - Follicular lymphoma

KW - Non-Hodgkin's lymphoma

KW - t(14 ;18)(q21 ;q34)

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JO - Leukemia Research

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High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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