High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Michael Green, Maher K. Gandhi, Emily Camilleri, Paula Marlton, Rod Lea, Lyn Griffiths

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown

Original languageEnglish (US)
Pages (from-to)731-734
Number of pages4
JournalLeukemia Research
Volume33
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Keywords

  • BACH2
  • BCL2
  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Non-Hodgkin's lymphoma
  • t(14 ;18)(q21 ;q34)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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