High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential

Naoaki Akisawa, Isao Nishimori, Takeshi Iwamura, Saburo Onishi, Michael A. Hollingsworth

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

Ezrin is a membrane cytoskeleton crosslinker protein that is a member of the ERM (ezrin/radixin/moesin) family. Ezrin binds adhesion molecules such as CD43, CD44, ICAM-1, and ICAM-2, which are implicated in cell migration and metastasis. Ezrin is expressed by many tumor cell lines; however, little is known about the function of ezrin in tumorigenesis and metastasis. Here, we investigated expression of ezrin in pancreatic adenocarcinoma cell lines of different metastatic potential. Among 16 pancreatic adenocarcinoma cell lines, several cell lines showed strong expression of ezrin. Two cell lines with high metastatic potential, S2-CP9 and S2-VP10, showed very high levels of ezrin mRNA and protein, whereas other sublines showed lower levels. There was no relationship between the expression levels of ezrin and the differentiation grades of the cell lines. These results suggest that there is a relationship between high expression of ezrin and metastatic potential of pancreatic carcinomas.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume258
Issue number2
DOIs
StatePublished - May 10 1999

Keywords

  • Carcinoma
  • Ezrin
  • Metastasis
  • Pancreas

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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