High-Resolution Solid-State NMR Applied to Polypeptides and Membrane Proteins

Sorin Luca, Henrike Heise, Marc Baldus

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly 13C,15N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.

Original languageEnglish (US)
Pages (from-to)858-865
Number of pages8
JournalAccounts of Chemical Research
Volume36
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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