High-Resolution Solid-State NMR Applied to Polypeptides and Membrane Proteins

Sorin Luca; Henrike Heise; Marc Baldus

doi:10.1021/ar020232y

High-Resolution Solid-State NMR Applied to Polypeptides and Membrane Proteins

Sorin Luca, Henrike Heise, Marc Baldus

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly ¹³C,¹⁵N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.

Original language	English (US)
Pages (from-to)	858-865
Number of pages	8
Journal	Accounts of Chemical Research
Volume	36
Issue number	11
DOIs	https://doi.org/10.1021/ar020232y
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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10.1021/ar020232y

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title = "High-Resolution Solid-State NMR Applied to Polypeptides and Membrane Proteins",

abstract = "Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly 13C,15N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.",

author = "Sorin Luca and Henrike Heise and Marc Baldus",

year = "2003",

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doi = "10.1021/ar020232y",

language = "English (US)",

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AU - Heise, Henrike

AU - Baldus, Marc

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N2 - Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly 13C,15N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.

AB - Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly 13C,15N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.

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U2 - 10.1021/ar020232y

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M3 - Review article

C2 - 14622033

AN - SCOPUS:0344393786

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JO - Accounts of Chemical Research

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High-Resolution Solid-State NMR Applied to Polypeptides and Membrane Proteins

Abstract

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