High-sensitivity detector for molecular sensing using magnetic particles

D. L. Roy; W. Yang; X. Yin; R. Y. Lai; S. H. Liou; D. J. Sellmyer

doi:10.1063/1.3564951

High-sensitivity detector for molecular sensing using magnetic particles

D. L. Roy, W. Yang, X. Yin, R. Y. Lai, S. H. Liou, D. J. Sellmyer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A scheme for molecular sensing using magnetic tracer particles and a microcantilever torsional magnetometer is investigated. The present report deals with the example of explosive 2,4,6-trinitrotoluene (TNT) detection. The sensors consist of silicon microcantilevers functionalized with TNT aptamers that are weakly bonded to magnetic particles via TNT-analog molecules. When exposed to TNT, the magnetic signal, initially maximum, is expected to undergo a steplike decrease as the TNT molecules replace the magnetic particles on the TNT receptors. We demonstrate the feasibility of this detection technique in terms of chemical reactions and our magnetometer sensitivity that reaches the range of 10 - 11 emu at room temperature with commercial atomic force microcopy cantilevers.

Original language	English (US)
Article number	07E532
Journal	Journal of Applied Physics
Volume	109
Issue number	7
DOIs	https://doi.org/10.1063/1.3564951
State	Published - Apr 1 2011

ASJC Scopus subject areas

General Physics and Astronomy

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title = "High-sensitivity detector for molecular sensing using magnetic particles",

abstract = "A scheme for molecular sensing using magnetic tracer particles and a microcantilever torsional magnetometer is investigated. The present report deals with the example of explosive 2,4,6-trinitrotoluene (TNT) detection. The sensors consist of silicon microcantilevers functionalized with TNT aptamers that are weakly bonded to magnetic particles via TNT-analog molecules. When exposed to TNT, the magnetic signal, initially maximum, is expected to undergo a steplike decrease as the TNT molecules replace the magnetic particles on the TNT receptors. We demonstrate the feasibility of this detection technique in terms of chemical reactions and our magnetometer sensitivity that reaches the range of 10 - 11 emu at room temperature with commercial atomic force microcopy cantilevers.",

author = "Roy, {D. L.} and W. Yang and X. Yin and Lai, {R. Y.} and Liou, {S. H.} and Sellmyer, {D. J.}",

note = "Funding Information: The authors are grateful to Professor Dussault for his knowledgeable support. This work is supported by DOD (ARO) W911NF-08-1-01311, W911NF-09-2-0039, NSF MRSEC DMR-0820521, and Nebraska Center for Materials and Nanoscience.",

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T1 - High-sensitivity detector for molecular sensing using magnetic particles

AU - Roy, D. L.

AU - Yang, W.

AU - Yin, X.

AU - Lai, R. Y.

AU - Liou, S. H.

AU - Sellmyer, D. J.

N1 - Funding Information: The authors are grateful to Professor Dussault for his knowledgeable support. This work is supported by DOD (ARO) W911NF-08-1-01311, W911NF-09-2-0039, NSF MRSEC DMR-0820521, and Nebraska Center for Materials and Nanoscience.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - A scheme for molecular sensing using magnetic tracer particles and a microcantilever torsional magnetometer is investigated. The present report deals with the example of explosive 2,4,6-trinitrotoluene (TNT) detection. The sensors consist of silicon microcantilevers functionalized with TNT aptamers that are weakly bonded to magnetic particles via TNT-analog molecules. When exposed to TNT, the magnetic signal, initially maximum, is expected to undergo a steplike decrease as the TNT molecules replace the magnetic particles on the TNT receptors. We demonstrate the feasibility of this detection technique in terms of chemical reactions and our magnetometer sensitivity that reaches the range of 10 - 11 emu at room temperature with commercial atomic force microcopy cantilevers.

AB - A scheme for molecular sensing using magnetic tracer particles and a microcantilever torsional magnetometer is investigated. The present report deals with the example of explosive 2,4,6-trinitrotoluene (TNT) detection. The sensors consist of silicon microcantilevers functionalized with TNT aptamers that are weakly bonded to magnetic particles via TNT-analog molecules. When exposed to TNT, the magnetic signal, initially maximum, is expected to undergo a steplike decrease as the TNT molecules replace the magnetic particles on the TNT receptors. We demonstrate the feasibility of this detection technique in terms of chemical reactions and our magnetometer sensitivity that reaches the range of 10 - 11 emu at room temperature with commercial atomic force microcopy cantilevers.

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High-sensitivity detector for molecular sensing using magnetic particles

Abstract

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