High-throughput computational and experimental biology strategy in identifying tumor expressing CAMs

Anguraj Sadanandam; Michelle L. Varney; Rakesh K. Singh

High-throughput computational and experimental biology strategy in identifying tumor expressing CAMs

Anguraj Sadanandam, Michelle L. Varney, Rakesh K. Singh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The combined strategy of experimental and computation biology in identifying Cell Adhesion Molecules (CAM) specific for tumors and organs was discussed. The filtering algorithm was used to identify specific hits to proteins involved in organ-specific hits to proteins involved in organ-specific interaction of cancer cells. Unique CAMs using sequence and pattern analysis with organ-specific peptides as query against mouse genome and proteome sequences were identified. The unique approaches developed to identify tumor-specific molecules, pave the way for complete understanding of role of the identified proteins in various steps of tumor metastasis and making organ specific targeting possible using these peptides.

Original language	English (US)
Title of host publication	Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004
Pages	450-451
Number of pages	2
State	Published - 2004
Event	Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004 - Stanford, CA, United States Duration: Aug 16 2004 → Aug 19 2004

Publication series

Name	Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004

Conference

Conference	Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004
Country/Territory	United States
City	Stanford, CA
Period	8/16/04 → 8/19/04

ASJC Scopus subject areas

General Engineering

Cite this

High-throughput computational and experimental biology strategy in identifying tumor expressing CAMs. / Sadanandam, Anguraj; Varney, Michelle L.; Singh, Rakesh K.
Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004. 2004. p. 450-451 (Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sadanandam, A, Varney, ML & Singh, RK 2004, High-throughput computational and experimental biology strategy in identifying tumor expressing CAMs. in Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004. Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004, pp. 450-451, Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004, Stanford, CA, United States, 8/16/04.

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abstract = "The combined strategy of experimental and computation biology in identifying Cell Adhesion Molecules (CAM) specific for tumors and organs was discussed. The filtering algorithm was used to identify specific hits to proteins involved in organ-specific hits to proteins involved in organ-specific interaction of cancer cells. Unique CAMs using sequence and pattern analysis with organ-specific peptides as query against mouse genome and proteome sequences were identified. The unique approaches developed to identify tumor-specific molecules, pave the way for complete understanding of role of the identified proteins in various steps of tumor metastasis and making organ specific targeting possible using these peptides.",

author = "Anguraj Sadanandam and Varney, {Michelle L.} and Singh, {Rakesh K.}",

year = "2004",

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note = "Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004 ; Conference date: 16-08-2004 Through 19-08-2004",

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AU - Varney, Michelle L.

AU - Singh, Rakesh K.

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N2 - The combined strategy of experimental and computation biology in identifying Cell Adhesion Molecules (CAM) specific for tumors and organs was discussed. The filtering algorithm was used to identify specific hits to proteins involved in organ-specific hits to proteins involved in organ-specific interaction of cancer cells. Unique CAMs using sequence and pattern analysis with organ-specific peptides as query against mouse genome and proteome sequences were identified. The unique approaches developed to identify tumor-specific molecules, pave the way for complete understanding of role of the identified proteins in various steps of tumor metastasis and making organ specific targeting possible using these peptides.

AB - The combined strategy of experimental and computation biology in identifying Cell Adhesion Molecules (CAM) specific for tumors and organs was discussed. The filtering algorithm was used to identify specific hits to proteins involved in organ-specific hits to proteins involved in organ-specific interaction of cancer cells. Unique CAMs using sequence and pattern analysis with organ-specific peptides as query against mouse genome and proteome sequences were identified. The unique approaches developed to identify tumor-specific molecules, pave the way for complete understanding of role of the identified proteins in various steps of tumor metastasis and making organ specific targeting possible using these peptides.

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M3 - Conference contribution

AN - SCOPUS:14044265081

SN - 0769521940

SN - 9780769521947

T3 - Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004

SP - 450

EP - 451

BT - Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004

T2 - Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004

Y2 - 16 August 2004 through 19 August 2004

ER -

High-throughput computational and experimental biology strategy in identifying tumor expressing CAMs

Abstract

Publication series

Conference

ASJC Scopus subject areas

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