TY - JOUR
T1 - Higher vaginal pH in Trichomonas vaginalis infection with intermediate Nugent score in reproductive-age women—a hospital-based cross-sectional study in Odisha, India
AU - Das, Padmalaya
AU - Swain, Tapoja
AU - Mohanty, Jyoti Ranjan
AU - Sinha, Shalini
AU - Padhi, Bijay
AU - Torondel, Belen
AU - Cumming, Oliver
AU - Panda, Bijaya
AU - Nayak, Arati
AU - Panigrahi, Pinaki
N1 - Funding Information:
We thank Prof Jane Carlton (Center for genomics and system biology, New York University, New York, USA) for providing TV positive isolates. We express our appreciation for the support from study participants, and hospital nurses for assisting in this project.
Funding Information:
Funding This work was supported by the UK Department for International Development through the Sanitation and Hygiene Applied Research for Equity (SHARE) consortium and intramural support from Asian Institute of Public Health (AIPH), Bhubaneswar, Odisha, India. However, the funding agencies had no involvement in study design, data collection, data analysis, and data interpretation, and the views expressed here do not necessarily reflect those of SHARE or AIPH.
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - A close association between Trichomonas vaginalis (TV) infection and bacterial vaginosis (BV) has been reported. Some other studies have found association is stronger with intermediate Nugent score than BV. Most studies have used wet mount microscopy, a relatively insensitive method, to detect TV infection. We wanted to study the association of TV infection with BV and with intermediate Nugent score. We undertook a cross-sectional hospital-based study of 1110 non-pregnant women from Odisha state, India, aged between 18 and 45 years, collecting vaginal swabs for diagnosis of BV by Nugent score (NS) criteria and TV by PCR analysis. TV infection was found in 13.3% of women with intermediate Nugent score (NS 4–6) and 13.6% with BV (NS 7–10). Before adjustment, TV infection was associated with BV, intermediate Nugent, vaginal pH ≥ 4.5, and age group between 26 and 35 years. Multivariate analysis confirmed that TV infection was more likely to have raised vaginal pH, either BV or intermediate Nugent. Proportion of TV cases increased sequentially with the increase in Nugent score up to NS 6, after which a decline was observed. Vaginal pH was higher in the TV-infected group than the uninfected group in women with intermediate Nugent, but no difference was noticed in women with BV. TV infection was equally prevalent in women with intermediate Nugent as well as BV. In the intermediate Nugent group women, TV infection was found only when vaginal pH was raised, indicating a crucial role of vaginal pH in determining TV infection.
AB - A close association between Trichomonas vaginalis (TV) infection and bacterial vaginosis (BV) has been reported. Some other studies have found association is stronger with intermediate Nugent score than BV. Most studies have used wet mount microscopy, a relatively insensitive method, to detect TV infection. We wanted to study the association of TV infection with BV and with intermediate Nugent score. We undertook a cross-sectional hospital-based study of 1110 non-pregnant women from Odisha state, India, aged between 18 and 45 years, collecting vaginal swabs for diagnosis of BV by Nugent score (NS) criteria and TV by PCR analysis. TV infection was found in 13.3% of women with intermediate Nugent score (NS 4–6) and 13.6% with BV (NS 7–10). Before adjustment, TV infection was associated with BV, intermediate Nugent, vaginal pH ≥ 4.5, and age group between 26 and 35 years. Multivariate analysis confirmed that TV infection was more likely to have raised vaginal pH, either BV or intermediate Nugent. Proportion of TV cases increased sequentially with the increase in Nugent score up to NS 6, after which a decline was observed. Vaginal pH was higher in the TV-infected group than the uninfected group in women with intermediate Nugent, but no difference was noticed in women with BV. TV infection was equally prevalent in women with intermediate Nugent as well as BV. In the intermediate Nugent group women, TV infection was found only when vaginal pH was raised, indicating a crucial role of vaginal pH in determining TV infection.
KW - Bacterial vaginosis
KW - Non-pregnant woman
KW - Nugent score
KW - Trichomonas vaginalis
KW - Vaginal pH
UR - http://www.scopus.com/inward/record.url?scp=85048989377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048989377&partnerID=8YFLogxK
U2 - 10.1007/s00436-018-5962-z
DO - 10.1007/s00436-018-5962-z
M3 - Article
C2 - 29936622
AN - SCOPUS:85048989377
SN - 0932-0113
VL - 117
SP - 2735
EP - 2742
JO - Parasitology research
JF - Parasitology research
IS - 9
ER -