Highly activated CD8+ T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection

M. C.G. Marcondes, E. M.E. Burudi, S. Huitron-Resendiz, M. Sanchez-Alavez, D. Watry, M. Zandonatti, S. J. Henriksen, H. S. Fox

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

One of the consequences of HIV infection is damage to the CNS. To characterize the virologic, immunologic, and functional factors involved in HIV-induced CNS disease, we analyzed the viral loads and T cell infiltrates in the brains of SIV-infected rbesus monkeys whose CNS function (sensory evoked potential) was impaired. Following infection, CNS evoked potentials were abnormal, indicating early CNS disease. Upon autopsy at 11 wk post-SIV inoculation, tbe brains of infected animals contained over 5-fold more CD8+ T cells than did uninfected controls. In both infected and uninfected groups, these CD8+ T cells presented distinct levels of activation markers (CD11a and CD95) at different sites: brain > CSF > spleen = blood > lymph nodes. The CD8+ cells obtained from the brains of infected monkeys expressed mRNA for cytolytic and proinflammatory molecules, such as granzymes A and B, perforin, and IFN-γ. Therefore, the neurological dysfunctions correlated with increased numbers of CD8+ T cells of an activated phenotype in the brain, suggesting that virus-host interactions contributed to the related CNS functional defects.

Original languageEnglish (US)
Pages (from-to)5429-5438
Number of pages10
JournalJournal of Immunology
Volume167
Issue number9
DOIs
StatePublished - Nov 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Marcondes, M. C. G., Burudi, E. M. E., Huitron-Resendiz, S., Sanchez-Alavez, M., Watry, D., Zandonatti, M., Henriksen, S. J., & Fox, H. S. (2001). Highly activated CD8+ T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. Journal of Immunology, 167(9), 5429-5438. https://doi.org/10.4049/jimmunol.167.9.5429