Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

Nasim Annabi; Su Ryon Shin; Ali Tamayol; Mario Miscuglio; Mohsen Afshar Bakooshli; Alexander Assmann; Pooria Mostafalu; Jeong Yun Sun; Suzanne Mithieux; Louis Cheung; Xiaowu Tang; Anthony S. Weiss; Ali Khademhosseini

doi:10.1002/adma.201503255

Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

Nasim Annabi, Su Ryon Shin, Ali Tamayol, Mario Miscuglio, Mohsen Afshar Bakooshli, Alexander Assmann, Pooria Mostafalu, Jeong Yun Sun, Suzanne Mithieux, Louis Cheung, Xiaowu Tang, Anthony S. Weiss, Ali Khademhosseini

Mechanical & Materials Engineering

Research output: Contribution to journal › Article

112 Scopus citations

Abstract

The aim of this study is to engineer a biocompatible and stretchable hydrogel with tunable mechanical, electrical, and biological properties based on recombinant human tropoelastin and graphene oxide (GO) nanoparticles. Tropoelastin is the dominant physiological component of elastin, where upon crosslinking it conveys both elasticity and biological activity. The study uses GO nanoparticles to form conductive and elastomeric methacryloyl-substituted tropoelastin (MeTro)/GO hybrid hydrogels. GO is utilized due to its flexibility, biocompatibility, and ease of dispersion in aqueous solutions.

Original language	English (US)
Pages (from-to)	40-49
Number of pages	10
Journal	Advanced Materials
Volume	28
Issue number	1
DOIs	https://doi.org/10.1002/adma.201503255
State	Published - Jan 1 2016

Fingerprint

Keywords

cardiac tissue engineering
elasticity
graphene oxides
hydrogels
tropoelastins

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

Annabi, N., Shin, S. R., Tamayol, A., Miscuglio, M., Bakooshli, M. A., Assmann, A., Mostafalu, P., Sun, J. Y., Mithieux, S., Cheung, L., Tang, X., Weiss, A. S., & Khademhosseini, A. (2016). Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels. Advanced Materials, 28(1), 40-49. https://doi.org/10.1002/adma.201503255

Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels. / Annabi, Nasim; Shin, Su Ryon; Tamayol, Ali; Miscuglio, Mario; Bakooshli, Mohsen Afshar; Assmann, Alexander; Mostafalu, Pooria; Sun, Jeong Yun; Mithieux, Suzanne; Cheung, Louis; Tang, Xiaowu; Weiss, Anthony S.; Khademhosseini, Ali.

In: Advanced Materials, Vol. 28, No. 1, 01.01.2016, p. 40-49.

Research output: Contribution to journal › Article

Annabi, Nasim ; Shin, Su Ryon ; Tamayol, Ali ; Miscuglio, Mario ; Bakooshli, Mohsen Afshar ; Assmann, Alexander ; Mostafalu, Pooria ; Sun, Jeong Yun ; Mithieux, Suzanne ; Cheung, Louis ; Tang, Xiaowu ; Weiss, Anthony S. ; Khademhosseini, Ali. / Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels. In: Advanced Materials. 2016 ; Vol. 28, No. 1. pp. 40-49.

@article{7e90ae611d6e4bf5a8071041980e24f5,

title = "Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels",

abstract = "The aim of this study is to engineer a biocompatible and stretchable hydrogel with tunable mechanical, electrical, and biological properties based on recombinant human tropoelastin and graphene oxide (GO) nanoparticles. Tropoelastin is the dominant physiological component of elastin, where upon crosslinking it conveys both elasticity and biological activity. The study uses GO nanoparticles to form conductive and elastomeric methacryloyl-substituted tropoelastin (MeTro)/GO hybrid hydrogels. GO is utilized due to its flexibility, biocompatibility, and ease of dispersion in aqueous solutions.",

keywords = "cardiac tissue engineering, elasticity, graphene oxides, hydrogels, tropoelastins",

author = "Nasim Annabi and Shin, {Su Ryon} and Ali Tamayol and Mario Miscuglio and Bakooshli, {Mohsen Afshar} and Alexander Assmann and Pooria Mostafalu and Sun, {Jeong Yun} and Suzanne Mithieux and Louis Cheung and Xiaowu Tang and Weiss, {Anthony S.} and Ali Khademhosseini",

year = "2016",

month = jan,

day = "1",

doi = "10.1002/adma.201503255",

language = "English (US)",

volume = "28",

pages = "40--49",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

AU - Annabi, Nasim

AU - Shin, Su Ryon

AU - Tamayol, Ali

AU - Miscuglio, Mario

AU - Bakooshli, Mohsen Afshar

AU - Assmann, Alexander

AU - Mostafalu, Pooria

AU - Sun, Jeong Yun

AU - Mithieux, Suzanne

AU - Cheung, Louis

AU - Tang, Xiaowu

AU - Weiss, Anthony S.

AU - Khademhosseini, Ali

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The aim of this study is to engineer a biocompatible and stretchable hydrogel with tunable mechanical, electrical, and biological properties based on recombinant human tropoelastin and graphene oxide (GO) nanoparticles. Tropoelastin is the dominant physiological component of elastin, where upon crosslinking it conveys both elasticity and biological activity. The study uses GO nanoparticles to form conductive and elastomeric methacryloyl-substituted tropoelastin (MeTro)/GO hybrid hydrogels. GO is utilized due to its flexibility, biocompatibility, and ease of dispersion in aqueous solutions.

AB - The aim of this study is to engineer a biocompatible and stretchable hydrogel with tunable mechanical, electrical, and biological properties based on recombinant human tropoelastin and graphene oxide (GO) nanoparticles. Tropoelastin is the dominant physiological component of elastin, where upon crosslinking it conveys both elasticity and biological activity. The study uses GO nanoparticles to form conductive and elastomeric methacryloyl-substituted tropoelastin (MeTro)/GO hybrid hydrogels. GO is utilized due to its flexibility, biocompatibility, and ease of dispersion in aqueous solutions.

KW - cardiac tissue engineering

KW - elasticity

KW - graphene oxides

KW - hydrogels

KW - tropoelastins

UR - http://www.scopus.com/inward/record.url?scp=84955192137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955192137&partnerID=8YFLogxK

U2 - 10.1002/adma.201503255

DO - 10.1002/adma.201503255

M3 - Article

C2 - 26551969

AN - SCOPUS:84955192137

VL - 28

SP - 40

EP - 49

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 1

ER -

Access to Document

10.1002/adma.201503255