Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

Nasim Annabi, Su Ryon Shin, Ali Tamayol, Mario Miscuglio, Mohsen Afshar Bakooshli, Alexander Assmann, Pooria Mostafalu, Jeong Yun Sun, Suzanne Mithieux, Louis Cheung, Xiaowu Tang, Anthony S. Weiss, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

The aim of this study is to engineer a biocompatible and stretchable hydrogel with tunable mechanical, electrical, and biological properties based on recombinant human tropoelastin and graphene oxide (GO) nanoparticles. Tropoelastin is the dominant physiological component of elastin, where upon crosslinking it conveys both elasticity and biological activity. The study uses GO nanoparticles to form conductive and elastomeric methacryloyl-substituted tropoelastin (MeTro)/GO hybrid hydrogels. GO is utilized due to its flexibility, biocompatibility, and ease of dispersion in aqueous solutions.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalAdvanced Materials
Volume28
Issue number1
DOIs
StatePublished - 2016

Keywords

  • cardiac tissue engineering
  • elasticity
  • graphene oxides
  • hydrogels
  • tropoelastins

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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