Hippocampus and spatial memory

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The hippocampus is a brain structure located inside the temporal lobe. It forms a part of the limbic system and plays an important role in the formation, consolidation and retrieval of episodic memories. It has been shown that repetitive activation of excitatory synapses in the hippocampus causes an increase in synaptic strength that last for hours or days designated as long-term potentiation (LTP). It is widely believed that LTP provides an important key to understand the cellular and molecular mechanisms by which memories and formed and stored. Sensory information enters the hippocampus mainly through the perforant pathway consisting of the axons of neurons in layer II and III of the entorhinal cortex. The perforant path axons terminate on the dendrites of the dentate gryus granular cells. Then information flow through the hippocampus from the dentate gyrus to the CA3, the CA1 and the subiculum, forming hippocampal intrinsic trisynaptic circuit. In addition to its traditional role in learning and memory, the hippocampus is also involved in neuroimmunity. Lesion of hippocampus alters immunity and neuronal functions in the hippocampus are modulated by a variety of immune active molecules.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer US
Pages55-64
Number of pages10
ISBN (Print)9780387725727
DOIs
StatePublished - 2008

Keywords

  • Amygdala
  • Cytokine
  • Dentate gyrus
  • EPSCs
  • EPSPs
  • Hippocampus
  • Limbic system
  • Long-term potentiation
  • NMDA receptor
  • Neurotransmitter
  • Spatial memory
  • Synapse
  • Temporal lobe

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Xiong, H. (2008). Hippocampus and spatial memory. In Neuroimmune Pharmacology (pp. 55-64). Springer US. https://doi.org/10.1007/978-0-387-72573-4_6