Histiocytic lymphoma and malignant angioendotheliomatosis. One disease or two?

Jack Ansell, Jag Bhawan, Samuel Cohen, John Sullivan, David Sherman

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


The case history of a patient with diffuse histiocytic lymphoma and skin lesions characteristic of malignant angioendotheliomatosis is reported. The patient initially responded to aggressive chemotherapy but quickly had a relapse, CNS disease developed, and the patient died one year after diagnosis. Microscopic, ultrastructural, and surface membrane studies showed that the intravascular tumor cells were not of endothelial origin. The morphologic similarity of the malignant intravascular cells and peripheral blood cells, as well as the demonstration of surface membrane immunoglobulin on malignant blood cells suggested that, in some cases, unusual features of malignant lymphoma may be confused with malignant angioendotheliomatosis.

Original languageEnglish (US)
Pages (from-to)1506-1512
Number of pages7
Issue number8
StatePublished - Oct 15 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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