Histologic analysis of chronic rejection in small bowel transplantation: Mucosal and vascular alterations

Benjamin J. Swanson; Geoffrey A. Talmon; James W. Wisecarver; Wendy J. Grant; Stanley J. Radio

doi:10.1097/TP.0b013e318270f370

Histologic analysis of chronic rejection in small bowel transplantation: Mucosal and vascular alterations

Benjamin J. Swanson, Geoffrey A. Talmon, James W. Wisecarver, Wendy J. Grant, Stanley J. Radio

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.

Original language	English (US)
Pages (from-to)	378-382
Number of pages	5
Journal	Transplantation
Volume	95
Issue number	2
DOIs	https://doi.org/10.1097/TP.0b013e318270f370
State	Published - Jan 27 2013

Keywords

Chronic rejection.
Small bowel
Transplantation

ASJC Scopus subject areas

Transplantation

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10.1097/TP.0b013e318270f370

Cite this

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title = "Histologic analysis of chronic rejection in small bowel transplantation: Mucosal and vascular alterations",

abstract = "BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.",

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AU - Swanson, Benjamin J.

AU - Talmon, Geoffrey A.

AU - Wisecarver, James W.

AU - Grant, Wendy J.

AU - Radio, Stanley J.

PY - 2013/1/27

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N2 - BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.

AB - BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.

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Histologic analysis of chronic rejection in small bowel transplantation: Mucosal and vascular alterations

Abstract

Keywords

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