Histologic analysis of chronic rejection in small bowel transplantation: Mucosal and vascular alterations

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13 Scopus citations

Abstract

BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalTransplantation
Volume95
Issue number2
DOIs
StatePublished - Jan 27 2013

Keywords

  • Chronic rejection.
  • Small bowel
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

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