Abstract
BACKGROUND: Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative. METHODS: We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa. RESULTS: Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection. CONCLUSION: These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.
Original language | English (US) |
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Pages (from-to) | 378-382 |
Number of pages | 5 |
Journal | Transplantation |
Volume | 95 |
Issue number | 2 |
DOIs | |
State | Published - Jan 27 2013 |
Keywords
- Chronic rejection.
- Small bowel
- Transplantation
ASJC Scopus subject areas
- Transplantation