Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices

James B. Graham; Eric W. Atkinson; Elizabeth A. Nunamaker; Benjamin S. Spearman; Vidhi H. Desai; Chancellor S. Shafor; Sruthi Natt; Rebecca A. Wachs; Christine E. Schmidt; Jack W. Judy; Kevin J. Otto

doi:10.1109/NER.2017.8008344

Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices

James B. Graham, Eric W. Atkinson, Elizabeth A. Nunamaker, Benjamin S. Spearman, Vidhi H. Desai, Chancellor S. Shafor, Sruthi Natt, Rebecca A. Wachs, Christine E. Schmidt, Jack W. Judy, Kevin J. Otto

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Neural-interface devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals of the peripheral nerve to and from electrical signals in instrumentation for stimulation and recording to produce fine control of advanced prosthetics. In order to potentiate the full spectrum of possible applications, the persistent foreign-body response needs to be addressed. Here we describe the cellular and extracellular components of chronically implanted polyimide threads suspended within a tricomponent hydrogel. The results of these experiments will contribute to design modifications for future fabrications of tissue-engineered-electronic-nerve-interface (TEENI) devices.

Original language	English (US)
Title of host publication	8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Publisher	IEEE Computer Society
Pages	275-278
Number of pages	4
ISBN (Electronic)	9781538619162
DOIs	https://doi.org/10.1109/NER.2017.8008344
State	Published - Aug 10 2017
Event	8th International IEEE EMBS Conference on Neural Engineering, NER 2017 - Shanghai, China Duration: May 25 2017 → May 28 2017

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Other

Other	8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Country/Territory	China
City	Shanghai
Period	5/25/17 → 5/28/17

ASJC Scopus subject areas

Artificial Intelligence
Mechanical Engineering

Access to Document

10.1109/NER.2017.8008344

Cite this

Graham, J. B., Atkinson, E. W., Nunamaker, E. A., Spearman, B. S., Desai, V. H., Shafor, C. S., Natt, S., Wachs, R. A., Schmidt, C. E., Judy, J. W., & Otto, K. J. (2017). Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017 (pp. 275-278). Article 8008344 (International IEEE/EMBS Conference on Neural Engineering, NER). IEEE Computer Society. https://doi.org/10.1109/NER.2017.8008344

Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices. / Graham, James B.; Atkinson, Eric W.; Nunamaker, Elizabeth A. et al.
8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society, 2017. p. 275-278 8008344 (International IEEE/EMBS Conference on Neural Engineering, NER).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Graham, JB, Atkinson, EW, Nunamaker, EA, Spearman, BS, Desai, VH, Shafor, CS, Natt, S, Wachs, RA, Schmidt, CE, Judy, JW & Otto, KJ 2017, Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices. in 8th International IEEE EMBS Conference on Neural Engineering, NER 2017., 8008344, International IEEE/EMBS Conference on Neural Engineering, NER, IEEE Computer Society, pp. 275-278, 8th International IEEE EMBS Conference on Neural Engineering, NER 2017, Shanghai, China, 5/25/17. https://doi.org/10.1109/NER.2017.8008344

Graham JB, Atkinson EW, Nunamaker EA, Spearman BS, Desai VH, Shafor CS et al. Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society. 2017. p. 275-278. 8008344. (International IEEE/EMBS Conference on Neural Engineering, NER). doi: 10.1109/NER.2017.8008344

@inproceedings{5b8fef8cf02243418dbcf70a2100f43b,

title = "Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices",

abstract = "Neural-interface devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals of the peripheral nerve to and from electrical signals in instrumentation for stimulation and recording to produce fine control of advanced prosthetics. In order to potentiate the full spectrum of possible applications, the persistent foreign-body response needs to be addressed. Here we describe the cellular and extracellular components of chronically implanted polyimide threads suspended within a tricomponent hydrogel. The results of these experiments will contribute to design modifications for future fabrications of tissue-engineered-electronic-nerve-interface (TEENI) devices.",

author = "Graham, {James B.} and Atkinson, {Eric W.} and Nunamaker, {Elizabeth A.} and Spearman, {Benjamin S.} and Desai, {Vidhi H.} and Shafor, {Chancellor S.} and Sruthi Natt and Wachs, {Rebecca A.} and Schmidt, {Christine E.} and Judy, {Jack W.} and Otto, {Kevin J.}",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 8th International IEEE EMBS Conference on Neural Engineering, NER 2017 ; Conference date: 25-05-2017 Through 28-05-2017",

year = "2017",

month = aug,

day = "10",

doi = "10.1109/NER.2017.8008344",

language = "English (US)",

series = "International IEEE/EMBS Conference on Neural Engineering, NER",

publisher = "IEEE Computer Society",

pages = "275--278",

booktitle = "8th International IEEE EMBS Conference on Neural Engineering, NER 2017",

}

TY - GEN

T1 - Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices

AU - Graham, James B.

AU - Atkinson, Eric W.

AU - Nunamaker, Elizabeth A.

AU - Spearman, Benjamin S.

AU - Desai, Vidhi H.

AU - Shafor, Chancellor S.

AU - Natt, Sruthi

AU - Wachs, Rebecca A.

AU - Schmidt, Christine E.

AU - Judy, Jack W.

AU - Otto, Kevin J.

PY - 2017/8/10

Y1 - 2017/8/10

N2 - Neural-interface devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals of the peripheral nerve to and from electrical signals in instrumentation for stimulation and recording to produce fine control of advanced prosthetics. In order to potentiate the full spectrum of possible applications, the persistent foreign-body response needs to be addressed. Here we describe the cellular and extracellular components of chronically implanted polyimide threads suspended within a tricomponent hydrogel. The results of these experiments will contribute to design modifications for future fabrications of tissue-engineered-electronic-nerve-interface (TEENI) devices.

AB - Neural-interface devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals of the peripheral nerve to and from electrical signals in instrumentation for stimulation and recording to produce fine control of advanced prosthetics. In order to potentiate the full spectrum of possible applications, the persistent foreign-body response needs to be addressed. Here we describe the cellular and extracellular components of chronically implanted polyimide threads suspended within a tricomponent hydrogel. The results of these experiments will contribute to design modifications for future fabrications of tissue-engineered-electronic-nerve-interface (TEENI) devices.

UR - http://www.scopus.com/inward/record.url?scp=85028617801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028617801&partnerID=8YFLogxK

U2 - 10.1109/NER.2017.8008344

DO - 10.1109/NER.2017.8008344

M3 - Conference contribution

AN - SCOPUS:85028617801

T3 - International IEEE/EMBS Conference on Neural Engineering, NER

SP - 275

EP - 278

BT - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017

PB - IEEE Computer Society

T2 - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017

Y2 - 25 May 2017 through 28 May 2017

ER -

Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this