Histopathological correlation of diffusion basis spectrum imaging metrics of a biopsy-proven inflammatory demyelinating brain lesion: A brief report

Afsaneh Shirani, Peng Sun, Robert E. Schmidt, Kathryn Trinkaus, Robert T. Naismith, Sheng Kwei Song, Anne H. Cross

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Diffusion basis spectrum imaging (DBSI) models diffusion-weighted magnetic resonance imaging (MRI) signals as a combination of discrete anisotropic diffusion tensors and a spectrum of isotropic diffusion tensors. Here, we report the histopathological correlates of DBSI in the biopsied brain tissue of a patient with an inflammatory demyelinating lesion typical of multiple sclerosis (MS). Increased radial diffusivity (marker of demyelination), decreased fiber fraction (apparent axonal density), elevated nonrestricted isotropic fraction (marker of vasogenic edema), but unchanged axial diffusivity (marker of integrity of residual axons) seen in the lesion appeared consistent with histopathological findings of inflammatory demyelination with relative axonal sparing. Our report supports the application of DBSI as a biomarker in human studies of MS.

Original languageEnglish (US)
Pages (from-to)1937-1941
Number of pages5
JournalMultiple Sclerosis Journal
Volume25
Issue number14
DOIs
StatePublished - Dec 1 2019

Keywords

  • Multiple sclerosis
  • biomarker
  • diffusion basis spectrum imaging
  • imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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