History of myeloid-derived suppressor cells

James E. Talmadge, Dmitry I. Gabrilovich

Research output: Contribution to journalReview article

566 Scopus citations


Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been identified as myeloid-derived suppressor cells (MDSCs). The study of MDSCs has provided a wealth of information regarding tumour pathobiology, has extended our understanding of neoplastic progression and has modified our approaches to immune adjuvant therapy. In this Timeline article, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment.

Original languageEnglish (US)
Pages (from-to)739-752
Number of pages14
JournalNature Reviews Cancer
Issue number10
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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