HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia

Adelina Holguin; Mwanza Banda; Elizabeth J. Willen; Costantine Malama; Kaseya O. Chiyenu; Victor C. Mudenda; Charles Wood

doi:10.1007/s10461-011-9988-9

HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia

Adelina Holguin, Mwanza Banda, Elizabeth J. Willen, Costantine Malama, Kaseya O. Chiyenu, Victor C. Mudenda, Charles Wood

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Zambia has substantially been affected by the HIV/AIDS epidemic with prevalence rates at 14% in a population estimated at 12 million. Yet, the extent of HIVassociated neurocognitive disorders (HAND) in this population remains to be clearly understood.Aseries of culturally appropriate neuropsychological (NP) assessments [International HIV Dementia Scale (IHDS), Color Trails Test 1 and 2, Grooved pegboard Test, and Time Gait Test] were used to test the effects of HIV on NP performance of HIV seropositive and seronegative individuals. Twenty-two percent HIV positive individuals ARV naïve met the criteria for IHDSdefined NP impairment. Gender significantly influenced the performance on NP tests with females performing more poorly compared to males. Larger studies that will accommodate gender differences and age are necessary to generate appropriate norms in Zambia in order to better assess the prevalence of HAND in the developing country setting.

Original language	English (US)
Pages (from-to)	1895-1901
Number of pages	7
Journal	AIDS and Behavior
Volume	15
Issue number	8
DOIs	https://doi.org/10.1007/s10461-011-9988-9
State	Published - Nov 2011

Keywords

HIV subtype C
HIV-associated neurocognitive disorders
NeuroAIDs
Sub-Saharan Africa

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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title = "HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia",

abstract = "Zambia has substantially been affected by the HIV/AIDS epidemic with prevalence rates at 14% in a population estimated at 12 million. Yet, the extent of HIVassociated neurocognitive disorders (HAND) in this population remains to be clearly understood.Aseries of culturally appropriate neuropsychological (NP) assessments [International HIV Dementia Scale (IHDS), Color Trails Test 1 and 2, Grooved pegboard Test, and Time Gait Test] were used to test the effects of HIV on NP performance of HIV seropositive and seronegative individuals. Twenty-two percent HIV positive individuals ARV na{\"i}ve met the criteria for IHDSdefined NP impairment. Gender significantly influenced the performance on NP tests with females performing more poorly compared to males. Larger studies that will accommodate gender differences and age are necessary to generate appropriate norms in Zambia in order to better assess the prevalence of HAND in the developing country setting.",

keywords = "HIV subtype C, HIV-associated neurocognitive disorders, NeuroAIDs, Sub-Saharan Africa",

author = "Adelina Holguin and Mwanza Banda and Willen, {Elizabeth J.} and Costantine Malama and Chiyenu, {Kaseya O.} and Mudenda, {Victor C.} and Charles Wood",

note = "Funding Information: Acknowledgments This study was supported in part by the NIH PHS grants R21MH080612-01, the Ruth L. Kirschstein National Research Service Award 1 T32 AIO60547, and the Fogarty International TW001429 to CW. AH was a Ruth L. Kirschstein fellow and supported by Fogarty D43TW001429-09S1; MB, CM and VCM were Fogarty Fellows. We thank Margaret Hamakala, Mary Mainza (neuropsychological examiners), and the clients for their participation in this study. We thank Dr. Esteban Gonzalez Diaz for translating the abstract to Spanish. A gracious thank you to the reviewers for their insightful and helpful suggestions.",

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AU - Mudenda, Victor C.

AU - Wood, Charles

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