TY - JOUR
T1 - HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise
T2 - Relevance for HIV-1-associated dementia
AU - Xiong, Huangui
AU - Zeng, Yong Chun
AU - Lewis, Travis
AU - Zheng, Jialin
AU - Persidsky, Yuri
AU - Gendelman, Howard E.
PY - 2000
Y1 - 2000
N2 - Viral and cellular products from HIV-1-infected and/or immune competent mononuclear phagocytes (MP) (brain macrophages and microglia) affect neuronal function during HIV-1-associated dementia (HAD). Neurotoxic MP factors include, but are not limited to, pro-inflammatory cytokines, chemokines, platelet activating factor, arachidonic acid and its metabolites, nitric oxide, progeny virions and viral structural and regulatory proteins. The mechanisms for immune-mediated neural injury in HAD, only now, are being unraveled. In this regard, we reviewed the current knowledge of how postmitotic neurons, which can neither divide nor be replaced, are damaged by MP secretory activities. Linking neuronal function with brain MP activation was made possible by placing viral and/or immune products onto neurons and measuring cell signaling events or through ex vivo electrophysiological tests on MP-treated brain slices. Such linkages are shown, in this report, by select demonstrations of MP factors which cause neuronal dysfunction in HAD.
AB - Viral and cellular products from HIV-1-infected and/or immune competent mononuclear phagocytes (MP) (brain macrophages and microglia) affect neuronal function during HIV-1-associated dementia (HAD). Neurotoxic MP factors include, but are not limited to, pro-inflammatory cytokines, chemokines, platelet activating factor, arachidonic acid and its metabolites, nitric oxide, progeny virions and viral structural and regulatory proteins. The mechanisms for immune-mediated neural injury in HAD, only now, are being unraveled. In this regard, we reviewed the current knowledge of how postmitotic neurons, which can neither divide nor be replaced, are damaged by MP secretory activities. Linking neuronal function with brain MP activation was made possible by placing viral and/or immune products onto neurons and measuring cell signaling events or through ex vivo electrophysiological tests on MP-treated brain slices. Such linkages are shown, in this report, by select demonstrations of MP factors which cause neuronal dysfunction in HAD.
KW - Chemokines
KW - Cytokines
KW - HIV-1
KW - HIV-1-associated dementia
KW - Neurotoxicity
KW - Viral structural and regulatory proteins
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M3 - Article
C2 - 10871761
AN - SCOPUS:0034041752
SN - 1355-0284
VL - 6
SP - S14-S23
JO - Journal of neurovirology
JF - Journal of neurovirology
IS - SUPPL. 1
ER -