HIV and Proteomics: What We Have Learned from High Throughput Studies

Kinga Grabowska, Emma Harwood, Pawel Ciborowski

Research output: Contribution to journalReview articlepeer-review


The accelerated development of technology over the last three decades has driven biological sciences to high-throughput profiling experiments, now broadly referred to as systems biology. The unprecedented improvement of analytical instrumentation has opened new avenues for more complex experimental designs and expands the knowledge in genomics, proteomics, and other omics fields. Despite the collective efforts of hundreds of researchers, gleaning all the expected information from omics experiments is still quite far. This paper summarizes what has been learned from high-throughput proteomics studies thus far, and what is believed should be done to reveal even more valuable information from such studies. It is drawn from the background in using proteomics to study human immunodeficiency virus 1 infection of macrophages and/or T cells, but it is believed that some conclusions will be more broadly applicable.

Original languageEnglish (US)
Article number2000040
JournalProteomics - Clinical Applications
Issue number1
StatePublished - Jan 2021


  • human immunodeficiency virus
  • innate immunity
  • macrophage
  • proteomics
  • systems biology
  • virus

ASJC Scopus subject areas

  • Clinical Biochemistry


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