HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study

Sharon Nichols; Elizabeth M. Mahoney; Patricia A. Sirois; Janice D. Bordeaux; James A. Stehbens; Katherine A. Loveland; Nancy Amodei; E. Gomperts; W. Y. Wong; F. Kaufman; M. Nelson; S. Pearson; M. Hilgartner; S. Cunningham-Rundles; I. Goldberg; W. K. Hoots; K. Loveland; M. Cantini; A. Willoughby; S. McKinlay; S. Donfield; C. Contant; C. T. Kisker; J. Stehbens; S. O'Conner; J. McKillip; P. Sirois; C. Sexauer; H. Huszti; F. Kiplinger; S. Hawk; S. Arkin; A. Forster; S. Swindells; S. Richard; J. Mangos; A. Scott; R. Davis; J. Lusher; I. Warrier; K. Baird-Cox; M. E. Eyster; D. Ungar; S. Neagley; A. Shapiro; J. Morris; G. Davignon; P. Mollen; B. Wicklund; A. Mehrhof

doi:10.1093/jpepsy/25.8.545

HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study

Sharon Nichols, Elizabeth M. Mahoney, Patricia A. Sirois, Janice D. Bordeaux, James A. Stehbens, Katherine A. Loveland, Nancy Amodei, E. Gomperts, W. Y. Wong, F. Kaufman, M. Nelson, S. Pearson, M. Hilgartner, S. Cunningham-Rundles, I. Goldberg, W. K. Hoots, K. Loveland, M. Cantini, A. Willoughby, S. McKinlayS. Donfield, C. Contant, C. T. Kisker, J. Stehbens, S. O'Conner, J. McKillip, P. Sirois, C. Sexauer, H. Huszti, F. Kiplinger, S. Hawk, S. Arkin, A. Forster, S. Swindells, S. Richard, J. Mangos, A. Scott, R. Davis, J. Lusher, I. Warrier, K. Baird-Cox, M. E. Eyster, D. Ungar, S. Neagley, A. Shapiro, J. Morris, G. Davignon, P. Mollen, B. Wicklund, A. Mehrhof

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Objective: To assess changes in adaptive, emotional, and behavioral functioning over four years in children and adolescents with hemophilia and with or without HIV infection and to evaluate the relationship of these changes to immune status. Methods: Participants were 277 HIV-seropositive and 126 HIV-seronegative boys with hemophilia. Participants with HIV infection were divided into three groups based on trajectory of immune functioning (CD4+ cell counts) over the course of the study. Caregivers completed the Vineland Adaptive Behavior Scales and Pediatric Behavior Scale (PBS). Results: Results showed declining Vineland Communication scores for participants with consistently poor immune functioning. These participants also started with more PBS Attention Deficit and Deviation symptoms, which then decreased more sharply than for other groups. Low CD4+ counts were consistently associated with more Health and Depression-Anxiety symptoms on the PBS. However, with few exceptions, group means remained within normal limits. Conclusions: According to their caregivers, boys with hemophilia and HIV infection showed considerable resilience with regard to adaptive behavior and emotional and behavioral problems. However, over time changes occurred in these areas that appear to be related to immune functioning.

Original language	English (US)
Pages (from-to)	545-556
Number of pages	12
Journal	Journal of pediatric psychology
Volume	25
Issue number	8
DOIs	https://doi.org/10.1093/jpepsy/25.8.545
State	Published - 2000

Keywords

Adaptive functioning
Behavior
Children and adolescents
HIV infection
Hemophilia
Pediatric AIDS

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology

Access to Document

10.1093/jpepsy/25.8.545

Cite this

Nichols, S., Mahoney, E. M., Sirois, P. A., Bordeaux, J. D., Stehbens, J. A., Loveland, K. A., Amodei, N., Gomperts, E., Wong, W. Y., Kaufman, F., Nelson, M., Pearson, S., Hilgartner, M., Cunningham-Rundles, S., Goldberg, I., Hoots, W. K., Loveland, K., Cantini, M., Willoughby, A., ... Mehrhof, A. (2000). HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study. Journal of pediatric psychology, 25(8), 545-556. https://doi.org/10.1093/jpepsy/25.8.545

HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study. / Nichols, Sharon; Mahoney, Elizabeth M.; Sirois, Patricia A. et al.
In: Journal of pediatric psychology, Vol. 25, No. 8, 2000, p. 545-556.

Research output: Contribution to journal › Article › peer-review

Nichols, S, Mahoney, EM, Sirois, PA, Bordeaux, JD, Stehbens, JA, Loveland, KA, Amodei, N, Gomperts, E, Wong, WY, Kaufman, F, Nelson, M, Pearson, S, Hilgartner, M, Cunningham-Rundles, S, Goldberg, I, Hoots, WK, Loveland, K, Cantini, M, Willoughby, A, McKinlay, S, Donfield, S, Contant, C, Kisker, CT, Stehbens, J, O'Conner, S, McKillip, J, Sirois, P, Sexauer, C, Huszti, H, Kiplinger, F, Hawk, S, Arkin, S, Forster, A, Swindells, S, Richard, S, Mangos, J, Scott, A, Davis, R, Lusher, J, Warrier, I, Baird-Cox, K, Eyster, ME, Ungar, D, Neagley, S, Shapiro, A, Morris, J, Davignon, G, Mollen, P, Wicklund, B & Mehrhof, A 2000, 'HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study', Journal of pediatric psychology, vol. 25, no. 8, pp. 545-556. https://doi.org/10.1093/jpepsy/25.8.545

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title = "HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study",

abstract = "Objective: To assess changes in adaptive, emotional, and behavioral functioning over four years in children and adolescents with hemophilia and with or without HIV infection and to evaluate the relationship of these changes to immune status. Methods: Participants were 277 HIV-seropositive and 126 HIV-seronegative boys with hemophilia. Participants with HIV infection were divided into three groups based on trajectory of immune functioning (CD4+ cell counts) over the course of the study. Caregivers completed the Vineland Adaptive Behavior Scales and Pediatric Behavior Scale (PBS). Results: Results showed declining Vineland Communication scores for participants with consistently poor immune functioning. These participants also started with more PBS Attention Deficit and Deviation symptoms, which then decreased more sharply than for other groups. Low CD4+ counts were consistently associated with more Health and Depression-Anxiety symptoms on the PBS. However, with few exceptions, group means remained within normal limits. Conclusions: According to their caregivers, boys with hemophilia and HIV infection showed considerable resilience with regard to adaptive behavior and emotional and behavioral problems. However, over time changes occurred in these areas that appear to be related to immune functioning.",

keywords = "Adaptive functioning, Behavior, Children and adolescents, HIV infection, Hemophilia, Pediatric AIDS",

author = "Sharon Nichols and Mahoney, {Elizabeth M.} and Sirois, {Patricia A.} and Bordeaux, {Janice D.} and Stehbens, {James A.} and Loveland, {Katherine A.} and Nancy Amodei and E. Gomperts and Wong, {W. Y.} and F. Kaufman and M. Nelson and S. Pearson and M. Hilgartner and S. Cunningham-Rundles and I. Goldberg and Hoots, {W. K.} and K. Loveland and M. Cantini and A. Willoughby and S. McKinlay and S. Donfield and C. Contant and Kisker, {C. T.} and J. Stehbens and S. O'Conner and J. McKillip and P. Sirois and C. Sexauer and H. Huszti and F. Kiplinger and S. Hawk and S. Arkin and A. Forster and S. Swindells and S. Richard and J. Mangos and A. Scott and R. Davis and J. Lusher and I. Warrier and K. Baird-Cox and Eyster, {M. E.} and D. Ungar and S. Neagley and A. Shapiro and J. Morris and G. Davignon and P. Mollen and B. Wicklund and A. Mehrhof",

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doi = "10.1093/jpepsy/25.8.545",

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AU - Nichols, Sharon

AU - Mahoney, Elizabeth M.

AU - Sirois, Patricia A.

AU - Bordeaux, Janice D.

AU - Stehbens, James A.

AU - Loveland, Katherine A.

AU - Amodei, Nancy

AU - Gomperts, E.

AU - Wong, W. Y.

AU - Kaufman, F.

AU - Nelson, M.

AU - Pearson, S.

AU - Hilgartner, M.

AU - Cunningham-Rundles, S.

AU - Goldberg, I.

AU - Hoots, W. K.

AU - Loveland, K.

AU - Cantini, M.

AU - Willoughby, A.

AU - McKinlay, S.

AU - Donfield, S.

AU - Contant, C.

AU - Kisker, C. T.

AU - Stehbens, J.

AU - O'Conner, S.

AU - McKillip, J.

AU - Sirois, P.

AU - Sexauer, C.

AU - Huszti, H.

AU - Kiplinger, F.

AU - Hawk, S.

AU - Arkin, S.

AU - Forster, A.

AU - Swindells, S.

AU - Richard, S.

AU - Mangos, J.

AU - Scott, A.

AU - Davis, R.

AU - Lusher, J.

AU - Warrier, I.

AU - Baird-Cox, K.

AU - Eyster, M. E.

AU - Ungar, D.

AU - Neagley, S.

AU - Shapiro, A.

AU - Morris, J.

AU - Davignon, G.

AU - Mollen, P.

AU - Wicklund, B.

AU - Mehrhof, A.

PY - 2000

Y1 - 2000

N2 - Objective: To assess changes in adaptive, emotional, and behavioral functioning over four years in children and adolescents with hemophilia and with or without HIV infection and to evaluate the relationship of these changes to immune status. Methods: Participants were 277 HIV-seropositive and 126 HIV-seronegative boys with hemophilia. Participants with HIV infection were divided into three groups based on trajectory of immune functioning (CD4+ cell counts) over the course of the study. Caregivers completed the Vineland Adaptive Behavior Scales and Pediatric Behavior Scale (PBS). Results: Results showed declining Vineland Communication scores for participants with consistently poor immune functioning. These participants also started with more PBS Attention Deficit and Deviation symptoms, which then decreased more sharply than for other groups. Low CD4+ counts were consistently associated with more Health and Depression-Anxiety symptoms on the PBS. However, with few exceptions, group means remained within normal limits. Conclusions: According to their caregivers, boys with hemophilia and HIV infection showed considerable resilience with regard to adaptive behavior and emotional and behavioral problems. However, over time changes occurred in these areas that appear to be related to immune functioning.

AB - Objective: To assess changes in adaptive, emotional, and behavioral functioning over four years in children and adolescents with hemophilia and with or without HIV infection and to evaluate the relationship of these changes to immune status. Methods: Participants were 277 HIV-seropositive and 126 HIV-seronegative boys with hemophilia. Participants with HIV infection were divided into three groups based on trajectory of immune functioning (CD4+ cell counts) over the course of the study. Caregivers completed the Vineland Adaptive Behavior Scales and Pediatric Behavior Scale (PBS). Results: Results showed declining Vineland Communication scores for participants with consistently poor immune functioning. These participants also started with more PBS Attention Deficit and Deviation symptoms, which then decreased more sharply than for other groups. Low CD4+ counts were consistently associated with more Health and Depression-Anxiety symptoms on the PBS. However, with few exceptions, group means remained within normal limits. Conclusions: According to their caregivers, boys with hemophilia and HIV infection showed considerable resilience with regard to adaptive behavior and emotional and behavioral problems. However, over time changes occurred in these areas that appear to be related to immune functioning.

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HIV-associated changes in adaptive, emotional and behavioral functioning in children and adolescents with hemophilia: Results from the Hemophilia Growth and Development Study

Abstract

Keywords

ASJC Scopus subject areas

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