Abstract
Epithelial and submucosal mesenchymal (SM) cells from human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months implies that the human gastrointestinal tract may serve as a site for primary infection and as a reservoir for the virus. Furthermore, HIV infection of SM cells may be an in vitro model of Kaposi's sarcoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-504 |
| Number of pages | 6 |
| Journal | Journal of Leukocyte Biology |
| Volume | 49 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- Acquired immune deficiency syndrome (AIDS)
- Cell culture models
- Kaposi's sarcoma
- Virus latency
- Virus persistence
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology