TY - JOUR
T1 - HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes
AU - Zepeda-Gomez, Sergio
AU - Montao-Loza, Aldo
AU - Zapata-Colindres, Juan Carlos
AU - Paz, Francisco
AU - Olivera-Martinez, Marco
AU - Lpez-Reyes, Alberto
AU - Granados, Julio
AU - Vargas-Alarcn, Gilberto
N1 - Funding Information:
This work was supported in part by grants from the Consejo Nacional de Ciencia y Tecnología, Mexico City, Mexico. The authors are grateful to the study participants. Institutional Review Board approval was obtained for all sample collections.
PY - 2009
Y1 - 2009
N2 - Autoimmune liver diseases are sometimes difficult to differentiate from hepatic overlap syndromes (OS). The objective of this study was to use polymorphic genetic markers to better distinguish clinical heterogeneity in autoimmune liver disease. Since autoimmunity is the result of autoantibody production we studied HLA-DR alleles in 20 patients with autoimmune hepatitis (AIH), 16 with primary biliary cirrhosis (PBC), 10 with OS, and in 99 ethnically matched healthy individuals. Patients with OS had significantly higher alkaline phosphatase and total bilirubin levels than patients with AIH. OS patients had a higher prevalence of positive antinuclear antibodies and a higher AIH score than patients with PBC. Patients with OS also had higher total immunoglobulin levels (IgG isotype) as compared to patients with PBC. We found in PBC patients a higher gene frequency of HLA-DR4 and DR1 as compared to healthy controls (p 0.03, OR 2.2 and p 0.004, OR 4.3, respectively) and to OS patients (p 0.01, OR 6.8, and p 0.004, OR 10.0, respectively). On the other hand, the gene frequency of HLADR5 was significantly decreased in the total group of patients as compared to healthy controls suggesting a protective role of this allele for developing autoimmune liver disease.
AB - Autoimmune liver diseases are sometimes difficult to differentiate from hepatic overlap syndromes (OS). The objective of this study was to use polymorphic genetic markers to better distinguish clinical heterogeneity in autoimmune liver disease. Since autoimmunity is the result of autoantibody production we studied HLA-DR alleles in 20 patients with autoimmune hepatitis (AIH), 16 with primary biliary cirrhosis (PBC), 10 with OS, and in 99 ethnically matched healthy individuals. Patients with OS had significantly higher alkaline phosphatase and total bilirubin levels than patients with AIH. OS patients had a higher prevalence of positive antinuclear antibodies and a higher AIH score than patients with PBC. Patients with OS also had higher total immunoglobulin levels (IgG isotype) as compared to patients with PBC. We found in PBC patients a higher gene frequency of HLA-DR4 and DR1 as compared to healthy controls (p 0.03, OR 2.2 and p 0.004, OR 4.3, respectively) and to OS patients (p 0.01, OR 6.8, and p 0.004, OR 10.0, respectively). On the other hand, the gene frequency of HLADR5 was significantly decreased in the total group of patients as compared to healthy controls suggesting a protective role of this allele for developing autoimmune liver disease.
KW - Autoimmune hepatitis
KW - Overlap syndrome
KW - Primary biliary cirrhosis
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U2 - 10.1080/08820130902846282
DO - 10.1080/08820130902846282
M3 - Article
C2 - 19811438
AN - SCOPUS:70350635455
SN - 0882-0139
VL - 38
SP - 276
EP - 283
JO - Immunological Investigations
JF - Immunological Investigations
IS - 3-4
ER -