Hodgkin's lymphoma in systemic lupus erythematosus

Sasha Bernatsky, R. Ramsey-Goldman, D. Isenberg, A. Rahman, M. A. Dooley, J. Sibley, J. F. Boivin, L. Joseph, J. Armitage, A. Zoma, A. Clarke

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Objective. In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose of our work was to describe the phenomenon of HL in SLE. Methods. A multi-site cohort of 9547 SLE subjects was assembled; HL cases were ascertained through cancer registry linkage, and the standardized incidence ratio (SIR) for HL was determined. We also performed a literature search for HL cases in SLE, and compared these with our sample. Finally, we pooled results from our cohort study with two large population-based cohort studies providing SIR estimates for HL in SLE. Results. Five cases of HL occurred in our SLE cohort during the observation interval, for an SIR of 2.4 (95% CI 0.8, 5.5). The literature review documented 13 HL case reports developing in patients with SLE. A pooled analysis combining our data with the other large cohort studies yielded a standardized incidence ratio of 3.16 (95% CI, 1.63-5.51) for HL in SLE. Conclusions. Data suggest that risk in SLE is increased not only for NHL, but also for other malignancies arising from B-lymphocytes, including HL.

Original languageEnglish (US)
Pages (from-to)830-832
Number of pages3
Issue number5
StatePublished - May 2007


  • Hodgkin's lymphoma
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)


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