TY - JOUR
T1 - Hoogsteen base-pairing revisited
T2 - Resolving a role in normal biological processes and human diseases
AU - Ghosal, Gargi
AU - Muniyappa, K.
N1 - Funding Information:
This research was supported by grants from the Department of Science and Technology, New Delhi. We apologize to all the researchers whose contributions were not included in this review due to space limitations.
PY - 2006/4/28
Y1 - 2006/4/28
N2 - For a long time since the discovery of an alternative type of hydrogen bonding between adenine and thymidine, termed Hoogsteen base-pairing, its biological role remained elusive. Recent experiments provide compelling evidence that Hoogsteen base pairs manifest in a gamut of nuclear processes encompassing gene expression, replication, recombination, and telomere length maintenance. An increasing number of proteins that have been shown to bind, unwind or cleave G-quadruplexes or triplexes with high specificity underscore their biological significance. In humans, the absence of these cellular factors or their dysfunction leads to a wide spectrum of genetic diseases including cancer, neurodegenerative syndromes, and a myriad of other disorders. Thus, development of clinically useful compounds that target G-quadruplexes or triplexes, and interfere with specific cellular processes, provides considerable promise for successful and improved treatment of human diseases.
AB - For a long time since the discovery of an alternative type of hydrogen bonding between adenine and thymidine, termed Hoogsteen base-pairing, its biological role remained elusive. Recent experiments provide compelling evidence that Hoogsteen base pairs manifest in a gamut of nuclear processes encompassing gene expression, replication, recombination, and telomere length maintenance. An increasing number of proteins that have been shown to bind, unwind or cleave G-quadruplexes or triplexes with high specificity underscore their biological significance. In humans, the absence of these cellular factors or their dysfunction leads to a wide spectrum of genetic diseases including cancer, neurodegenerative syndromes, and a myriad of other disorders. Thus, development of clinically useful compounds that target G-quadruplexes or triplexes, and interfere with specific cellular processes, provides considerable promise for successful and improved treatment of human diseases.
KW - DNA transactions
KW - G-quadruplexes
KW - Genetic diseases
KW - Hoogsteen base-pairing
KW - RecQ helicases
KW - Triplexes
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U2 - 10.1016/j.bbrc.2006.02.148
DO - 10.1016/j.bbrc.2006.02.148
M3 - Short survey
C2 - 16540083
AN - SCOPUS:33645096882
SN - 0006-291X
VL - 343
SP - 1
EP - 7
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -