Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis

Seema Singh, Michelle Varney, Rakesh K. Singh

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Crucial steps in tumor growth and metastasis are proliferation, survival, and neovascularization. Previously, we have shown that receptors for CXCL-8, CXCR1, and CXCR2 are expressed on endothelial cells and CXCR2 has been shown to be a putative receptor for angiogenic chemokines. In this report, we examined whether tumor angiogenesis and growth of CXCL-8-expressing human melanoma cells are regulated in vivo by a host CXCR2-dependent mechanism. We generated mCXCR2-/-, mCXCR2+/-, and wild-type nude mice following crosses between BALB/c mice heterozygous for nude+/- and heterozygous for mCXCR2+/-. We observed a significant inhibition of human melanoma tumor growth and experimental lung metastasis in mCXCR2-/- mice as compared with wildtype nude mice. Inhibition in tumor growth and metastasis was associated with a decrease in melanoma cell proliferation, survival, inflammatory response, and angiogenesis. Together, these studies show the importance of host CXCR2-dependent CXCL-8-mediated angiogenesis in the regulation of melanoma growth and metastasis.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalCancer Research
Volume69
Issue number2
DOIs
StatePublished - Jan 15 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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