Host nuclear factor-κB activation potentiates lung cancer metastasis

Georgios T. Stathopoulos, Taylor P. Sherrill, Wei Han, Ruxana T. Sadikot, Fiona E. Yull, Timothy S. Blackwell, Barbara Fingleton

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Epidemiologic and experimental evidence suggests that a link exists between inflammation and cancer, although this relationship has only recently begun to be elucidated for lung cancer, the most frequently fatal human tumor. Nuclear factor-κB (NF-κB), a transcription factor that controls innate immune responses in the lungs, has been implicated as an important determinant of cancer cell proliferative and metastatic potential; however, its role in lung tumorigenesis is uncertain. Here, we specifically examine the role of NF-κB-induced airway inflammation in lung cancer metastasis using a model of intravenous injection of Lewis lung carcinoma cells into immunocompetent C57Bl/6 mice. Induction of lung inflammation by direct and specific NF-κB activation in airway epithelial cells potentiates lung adenocarcinoma metastasis. Moreover, we identify resident lung macrophages as crucial effectors of lung susceptibility to metastatic cancer growth. We conclude that NF-κB activity in host tissue is a significant factor in the development of lung metastasis.

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalMolecular Cancer Research
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Oncology
  • Cancer Research

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