How to compute which genes control drug resistance dynamics

Yunqian Guo, Jiangtao Luo, Jianxin Wang, Yaqun Wang, Rongling Wu

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Increasing evidence shows that genes have a pivotal role in affecting the dynamic pattern of viral loads in the body of a host. By reviewing the biochemical interactions between a virus and host cells as a dynamic system, we outline a computational approach for mapping the genetic control of virus dynamics. The approach integrates differential equations (DEs) to quantify the dynamic origin and behavior of a viral infection system. It enables geneticists to generate various testable hypotheses about the genetic control mechanisms for virus dynamics and infection. The experiment designed according to this approach will also enable researchers to gain insight into the role of genes in limiting virus abundance and the dynamics of viral drug resistance, facilitating the development of personalized medicines to eliminate viral infections.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalDrug Discovery Today
Volume16
Issue number7-8
DOIs
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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